2001 - maintenantCurrently: Deputy project leader and chemistry team leader in a project for the treatment of Gram-negative infections, from lead optimization to preclinical studies.
- Interpretation of biological data (in Vivo and in Vitro) and consequently the coordination of the chemistry priorities, scientific and technical support for the different members of the team (up to 40 chemists for the project). Preparation of necessary reports, patents and publications.
- Close collaborations and proactive interactions with different department.
- Technical operation department for API synthesis; the role includes technical transfer and support for APIs synthesis from laboratory to production scale with external partners.
- Technical operation department for analytical and preformulation studies; the role includes salts preparation for improving solubility and stability of the API.
From 2002 to 2004: Project manager, support to process development for the manufacturing of Ceftobiprole;
- Elaboration of synthetic pathways for the preparation of reference compounds required for In Process Control. Close collaboration with Technical operation department for analytical
- Process research and trouble shooting activities during the manufacturing of API.
From 2001 to 2005: Corporate activities
- Active participation to the creation of the Research Center in China (Basilea China, Haimen, 50 FTEs), Providing technical and practical advices for building chemistry labs and active participation of implementing reporting and communication system.
- Management of a team responsible of the Purification and Plating Platform; the platform offers a large range of technologies for identification and purification (from mg up to few g scale) from single compound to small libraries, as well as compounds delivery via 96-well plates for biological tests.
- Implementation and Management of Compound Depository Team; Team leader for the creation and the implementation of Compound Depository Service in Basilea.
Pharmacia & Upjohn (Stockholm)
- Chimiste medicinal au sein du departement recherche
1997 - 2001- Active participation, as medicinal chemist and chemistry team leader, within 4 different projects (Protein-protein interaction, G-protein coupled receptor and enzyme inhibitor) at different stages of the drug discovery process (hit to lead to lead optimisation).
- Chemistry team leader managing a team of 9 chemists (graduate and PhD level) in a specific project. The role includes the interpretation of biological data and consequently the coordination of the chemistry priorities between the different members of the team.
- Close interactions with, biologists, pharmacologists and preclinical scientists for interpretation of in Vitro and in Vivo data.
- Close interactions with computational chemists for designing libraries.
- Practical experience of building focused libraries in solution or using polymer-assisted reagents. Familiar with modern purification techniques (analytical and preparative HPLC, LC/MS, etc.).
- Liaison with external collaboration
