PHILADELPHIA
Project manager: 2008-Present
Division of Hematology/Oncology, University of Pennsylvania School of Medicine (Philadelphia, USA) in collaboration with the Department of Biological Sciences (SANOFI-AVENTIS, Bridgewater, USA).
Characterization of leukemic stem cells:
ß Characterizing acute myelogenous leukemia-initiating cells by xenotransplantation in immunodeficient mice.
ß Developing a screening of monoclonal antibodies targeting specifically the AML stem cells.
ß Supervising two research specialists in daily work. Analysing results, making training, reports and presentations.
Research associate: 2006-2009
Division of Hematology/Oncology, University of Pennsylvania School of Medicine (Philadelphia, USA).
Mitochondrial and energetic metabolism as therapeutic targets in myeloproliferative disorders and leukemia:
ß Analyzed leukemic cell energetic metabolism by proteomic, functional and metabolic profiling;
Blood mitochondrial biomarkers in human neurological disorders.
ß Identified blood mitochondrial biomarkers in Friedreich ataxia.
ß Collaboration: Identified hippocampal biomarkers of neurotrophin NT4 efficacy during traumatic brain injury.
Post-doctoral fellow: 2001-2005
Department of Biology, University of Pennsylvania (Philadelphia, USA, 2003-2005).
Commissariat Energie Atomique (Grenoble, France, 2001-2003).
Proteomic and metabolomic approaches for dissecting the yeast and plant responses to metal toxity.
ß Identified and characterized 3 proteins (GST, MBP, Met17p).
ß Collaboration: Identified thiol metabolites biomarkers of metal toxicity.
ß Managed lab supplies purchases, supervised radioisotope usage and MALDI-ToF mass spectrometry in the laboratory.
Mes compétences :
Biology
Cell Biology
Discovery
Drug discovery
Oncology
proteomics
Research
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