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Loïc TOMAS

BIOT

En résumé

Strong knowledge of organic chemistry, multi-step synthesis and techniques of purification and analysis of organic compounds.
Ability to solve problems and to propose suitable alternatives to obtain the targeted products/improve a process.
Experience of R&D project management. Administration of in/out-sourcing projects.
Management of a team of chemists.
Student teaching and management.

Speciality :
R&D, pharmaceutical industry, Synthetic strategy, Total synthesis of Natural Compounds and Scientific project management. Medicinal chemistry
Experience in scale-up and optimization of processes for piloting campaign.

Analyticals: HPLC, GC, NMR (1D & 2D), LCMS, IR, UV

Mes compétences :
chimie organique
génie des procédés
Multi-steps synthesis
Coaching
Transition metal catalyzed coupling
Process improvement
Medicinal chemistry
Organic chemistry
Chemistry
Leadership
Heterocyclic chemistry
Management

Entreprises

  • Nestlé skin Health - Synthesis Team Manager in Research Chemistry

    2014 - maintenant Key achievements:
     Driving of a team of chemists internally & externally to deliver complex and innovative synthetic routes leading to the nomination of 3 development compounds for psoriasis treatment.

     Contribution into the overall group synthesis strategy, training and yearly objective setting with a net result > 60% increase in key performance indicators (KPI) and participation in a Lean Six Sigma green belt project to drive project delivery.

     Launch & development of a new flow chemistry platform to support high-throughput drug delivery (acne/ skin cancer) and biomaterials synthesis (skin wrinkle filler).

     Involvement in 4 publications and external presentations surrounding breakthrough synthetic routes or methodologies for prescription (Rx) or aesthetic & corrective (A&C) programs.

     HSE chemistry manager of Research Chemistry (~30 scientists), execution of behavior based safety (BBS) process and realization of the laboratory refurbishment for improved laboratory productivity & ergonomics (100k€ budget).

  • Galderma - Lead Synthetic Scientist

    Courbevoie 2012 - maintenant Key achievements:
     Co-led the synthesis internally & externally and management of fee for service (FFS) requests to deliver three development candidates (rosacea) and one lead series for skin cancer (CTCL) treatment.

     Member of internal chemistry medchem/devchem problem-solving group and the innovation group in the A&C field (patents pending on hydrogel chemistry).

     Application of lean methodologies to synthesis by generation of right first-time conditions database on key transformations and strategic laboratory layout.

     Monthly training sessions given to internal chemists on retrosynthesis, route selection and structural analysis.

  • Laboratoire de Synthèse Totale et Réactivité Organique, Aix-Marseille III, France - Postdoctoral associate in total synthesis

    2010 - 2012 Postdoctoral position in total synthesis of natural products and analogs of callystatin A under the direction of Pr. J-M. Pons & Dr. C. Bressy
    Key achievements:
     Three fragments (4, 15 and 13 steps) convergent synthesis enabled by enzymatic enantioselective desymmetrization of meso diols, diastereoselective crotylstannylation, transition metal catalyzed reactions (Pd, Rh) and cross coupling metathesis.

     Self-managed a multidisciplinary project and animated/participated to weekly scientific seminars.

  • Université Claude Bernard Lyon I / Laboratoire de Chimie Organique II - Ph. D. in total synthesis of Bistramide A

    2007 - 2010 PhD fellowship granted by the French Ministry of Research in synthesis of natural spiroketal compounds;
    Key achievements:
     Development and optimization of a new enol ether formation based on Julia-Kocienski olefination of a lactone. Application to spiroketal synthesis (Spiket, Bistramide A, Attenol A).
     Regular scientific communications and mentoring of students (3MSc + 1Ph.D).
     Independent project on Attenol A total synthesis.

  • Université Claude Bernard Lyon I - CPE Lyon - Teaching assistant in Organic Chemistry

    2007 - 2010  Teaching assistant in Organic Chemistry (UCBL1 and CPE), practical work and tutorial (290h).

  • Rhodia Inc. PPD, Charleston, SC, USA - CHEMIST RESEARCHER INTERN

    2005 - 2006 Organophosphorus performance compound synthesis, development and production.

    Key achievements:
     Improved a process for scale-up, set up a GC routine analysis and piloted the production.

     Monthly presented progress report to team leader and customer

  • Labo-Services, Givors, France - ANALYTICAL CHEMIST INTERN

    2004 - 2004 Organic waste analyses by gas chromatography, Titration and X ray-fluorescence

Formations

  • Université Lyon 1 Claude Bernard / Laboratoire De Chimie Organique II–Glycochimie, Lyon, France.

    Villeurbanne 2007 - 2010 Ph.D. IN TOTAL SYNTHESIS OF BISTRAMIDE A (GRANTED BY THE MINISTRY OF RESEARCH)

    Key achievements:
     Developed and optimized a new methodology for spiroketal synthesis that led to the total synthesis (31 linear steps) of Bistramide A (4 publications).

     Regular scientific communications and mentoring of students (3MSc + 1Ph.D).

  • Université Lyon 1 Claude Bernard

    Villeurbanne 2006 - 2007 MASTERS DEGREE

    Masters with honors

  • Chimie Physique Electronique De Lyon

    Villeurbanne 2001 - 2007 DIPLOMA IN CHEMISTRY AND PROCESS ENGINEERING (HE 5)

    2003-2007: Complete education in organic and molecular chemistry, catalysis, analytical sciences, biology and process engineering.
    2001-2003: Two years of full-time higher education in Mathematics, Science and General Studies, in preparation for selective admission to CPE Lyon.
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