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Marc DE GASPARO

RUEIL MALMAISON

En résumé

Marc de Gasparo, MD is the founder of MG Consulting Co. He received a medical degree from the Catholic University of Louvain, was a research fellow at the Medical Clinic at University Hospital in Louvain and had clinical training at the Gestational Endocrinopathy Outpatient Clinic. After working in the Department of Biochemistry at the University of California, San Francisco, Dr. de Gasparo joined the Research Department of the Pharmaceutical Division of Ciba-Geigy, Basel, where he first described the selective aldosterone receptor antagonist eplerenone. In addition, he first reported the existence of two angiotensin II receptor subtypes and developed valsartan, a non-peptidic angiotensin II receptor antagonist. He also described the involvement of tyrosine phosphatases in the signaling mechanism of the AT2 receptor. Dr. de Gasparo is the author of more than 190 publications in the fields of diabetes mellitus, insulin chemistry, developmental biochemistry, hypertension, and the renin-angiotensin-aldosterone system including 3 chapters in books on Hypertension. Retired from Novartis, he is still active in these fields, advising various pharmaceutical companies, writing, lecturing and editing. Until Dec 2004, he chaired the IUPHAR subcommittee for the nomenclature of the angiotensin receptor, is a member of the Editorial Board of the Journal of Cardiovascular Pharmacology and regular reviewer for various journals.

Mes compétences :
Diabète
Hypertension
Pharmacologie

Entreprises

  • Novartis - Project Leader

    RUEIL MALMAISON 1997 - maintenant Development of valsartan (Diovan®): preclinical support; scientific meetings.(J Hypertension 1998,16,843; Pharmacology & Toxicology 1998, 82, 257; JRAAS 2000,1,151; Cardiovascular Drug Review 2001,1,75).
  • Ciba-Geigy-Novartis - Group Leader-Project leader

    1985 - maintenant Discovery and development of a new aldosterone receptor antagonist (epoxymexrenone or eplerenone) without the side-effect of aldactone (JPET 1987,240, 650)
    Discovery and characterization of two angiotensin receptors AT1 and AT2 (BBRC 1989,163,284; Regulatory peptides 1999,81,11; Pharmacological Reviews 2000,52,415).
    Description and preclinical characterization of the angiotensin receptor antagonist valsartan commercialized under the trade name of Diovan® (Br J PHarmacol 1993, 110, 761).
    Preclinical support to Diovan (J Hypertens 1998,16, 843; JRAAS 2001,1,151; Cardiovasc drug reviews 2001,19,75; IDrugs 2001,4,1043; Exp Clin Cardiol 2001,6,215; J Cardiovasc Pharmacol 2002,40,789.
    US Patents: 6174910; 6204281; 6211217;6395728; 6465502

Formations

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