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Hôpital Européen Georges Pompidou
- Biostatistician
2016 - maintenant
- Sample size estimation
- Writing the statistical part of the protocol
- Writing statistical analysis plans (SAP) and statistical reports
- Statistical analyses with SAS
- Logistic regression
- Multiple regression
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CHRU de Lille
- Biostatisticien
Lille
2014 - 2016
- Provides statistical input into protocol and case report form (CRF) (e.g. statistical methods for protocol, trial design, randomization...)
- Statistical methodology and sample size estimation ;
- Writing statistical analysis plans (SAP) and statistical reports
- Realization of statistical analysis (development and validation programs under SAS, Stata, and R)
- Interacts with other departments (data management, clinical research associate, scientific affairs, etc)
- With the medical writer, co-authors final integrated reports of clinical trial data by writing thorough and clear statistical methods sections and producing the statistical appendix for the final report
- Research and definition of statistical methods to implement (bibliography, analysis strategy,...)
- Writing scientific articles ;
- Valorisation of the results (publications, participates to conference, posters,...)
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University of Manitoba
- Biostatistical Research Intern
2014 - 2014
Sensitivity analysis of a prediction model used to estimate completeness of physician claims databases
- Evaluation of the factors that influence the performance of a predictive non- linear regression model constructed in a derivation sample and then applied to an independent external validation sample
- Estimate the completeness of physician billing claims databases for diabetes. Analysis were done with SAS.
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McGill University
- Biostatistical Research Intern
2013 - 2013
Overfitting of propensity score models-does it matter?
- Evaluation of the impact of overfitting of propensity score models when estimating true underlying probabilities to receive treatment
- See how inaccuracies in these estimates translate to erroneous estimates of treatment effects. Analysis were done with R and SAS.
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Faculty of Medicine of Strasbourg
- Biostatistical Research Intern
2012 - 2012
Computation of the intra-class correlation coefficient and predictive probabilities
- Calculation of intra-class correlation coefficients using mixed effect models.
- Calculation of predictive probabilities in the framework of the comparison of two proportions for the control of a clinical trial comparing two treatments using Bayesian approach. Analysis were done with R.
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CHUV Centre Hospitalier Universitaire Vaudois
- Biostatistical Research Intern
2012 - 2012
Relationship between urinary uromoduline and renal function in CoLaus (Cohorte Lausannoise) population study
- Relationship between uromoduline and renal function, using linear regression models
- Relationship between uromoduline and serum uric acid using linear regression models. Analysis were done with SAS and R.
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Centre for Clinical Epidemiology
- Biostatistical Research Intern
2011 - 2011
Using propensity score for meta-epidemiological study in randomized controlled trials
From an example of a meta-epidemiological study comparing estimation of treatment effect between single centre trials and multi centre trials on 48 meta-analyses, we compared results with classic model in two steps, a multilevel model allowing a multivariate analyse, and an adjusted model on the propensity to be a single centre trial. Analysis were done with SAS.
Articles Submitted and in Process
Kouokam W., Kramar A., Duhamel A., Penel N., Joly F., Filleron T., Houédé N. Statistical Controversies in Clinical Research: should schedules of tumor size assessments be changed? Soumis dans Annals of Oncology Journal.
Lix M. Lix, Xue Yao, George Kephart, Hude Quan, Mark Smith, John Paul Kuwornu, Nitharsana Manoharan, Wilfrid Kouokam, Khokan Sikdar. A Prediction Model to Estimate Completeness of Electronic Physician Claims Databases. Accepté pour publication dans le BMJ Open, Mai 2015.
Schuster T., Kouokam W., Platt R. Propensity Score Model Overfitting Leads to Inflated Variance of Estimated Odds Ratios. Soumis dans Journal of Clinical Epidemiology (en cours de revision).
Sajobi T., Pordeli P., Gurbakhshash S., Oluwaseyi L., Kouokam W., Lix L.M. Logistic Ridge Regression for Domain Importance Assessment in Health-Related Quality of Life Studies. En cours de soumission
Bochud M., Kouokam W., Vollenweider P., Devuice O. Relationship between urinary uromoduline and renal function. En cours de soumission
