Benoit RHONE

En résumé

Entreprises

• Gecko biomedical - Research engineer

  2018 - maintenant

• Heatself - Research engineer

  2017 - 2018 - Research and development of self-regulating cables for new applications in automotive, and space industry. Use of semi-conductive polymer formulations in order to develop innovative heating devices with self regulating properties. These heating devices find applications in multiple industrial fields needing electrical heating solutions.
  - Research and development of temperature sensors for aerospatial industry
  - Technological watch on competitors products and innovations and trends in electrical heating devices (industrial and academic)
  - Quality management of production to improve existing procedures (involved in ISO9001 :2015 certification and CSTB certification). Compliance of our procedures with existing norms (VDE, IEEE) in heating cable industry.

• Chimie ParisTech - PhD student (CIFRE with Vygon)

  2013 - 2016 CIFRE PhD program, in partnership with Vygon, a medical device company.
  Development of a chemical modification of polyurethane surfaces to improve biocompatibility of catheters. Innovation in order to get a new product on the market.
  Step n°1: screening of organic chemistry reactions on model carbamates to identify suitable reactions to efficiently modify polyurethanes
  Step n°2: optimisation of reaction conditions, study of the impact of various parameters on the yield of the chosen reaction
  Step n°3: apply this reaction to the surface modification of medical grade polyurethanes to modify its surface properties
  Step n°4: analyse the chemical and physical modification of the surface - TOF-SIMS, XPS, contact angle, profilometry, ATR-FTIR
  Step n°5: assess the biological properties of the modified surface towards blood coagulation and bacterial adhesion - protein adsorption, cell adhesion, platelet adhesion, bacterial adhesion
  
  Regular communication of results to Vygon project leaders and R&D director by means of regular reports and meetings.
  
  My results led to the redaction of a patent (EP3243861), two scientific articles (https://avs.scitation.org/doi/10.1116/1.5024601, https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0036-1588866) and one more to come.
  
  Communications to international seminars and congresses in front of an audience of experts in the field.

• GlaxoSmithKline - Chercheur associé en chimie médicinale

  Marly-le-Roi 2013 - 2013 GlaxoSmithKline, Philadelphie (USA) : projet de fin d'études. (ren.2.xie@gsk.com)
  Recherche et développement de molécules actives contre une maladie respiratoire
  * Recherche bibliographique, synthèse multi-étapes, optimisation de voies de synthèse
  * Étude des relations structure-activité, modélisation 3D des interactions entre la molécule et le substrat
  * Communication orale et écrite, animation de réunions de groupe

• GlaxoSmithKline - Organic chemist in a medicinal chemistry team

  Marly-le-Roi 2011 - 2012 *Synthesis of bioactive compounds against a respiratory disease. Organic chemistry, purification and analysis of hundreds of compounds. Litterature research to improve the yields of different synthesis.
  * Presentation of my work every week to the whole team.
  * Submitted ideas to improve the potency or the physical properties of the molecules.
  * Redaction of reports with the objective of a patent writing

• Laboratoires Boiron - Stage d'expérience

  Sainte-Foy-lès-Lyon 2010 - 2010 Working as a laboratory technician, I was doing dilutions and preparation of the medicines. As part of a team, I learned how to work with people, to help and be helped

• Bayer - Lab technician

  Lyon 2009 - 2009 Use of a liquid transfer robot to weigh out precise quantities of procducts stored in vials.
  Registration of the new compounds into a database of thousands of compounds.
  

Formations

• UPMC

  Paris 2013 - 2016 Doctorat en chimie des biomatériaux
  
  Doctorant CIFRE à Chimie ParisTech - contrat industriel avec Vygon (Directeur de thèse : Dr V. Semetey vincent.semetey@chimie-paristech.fr)
  « Modification de surfaces de polymères biomédicaux pour augmenter leur biocompatibilité »
  - Chimie organique en solution et formulation appliqués aux surfaces de matériaux, étude des propriétés biologiques et mécaniques des matériaux
  - Chimie des polymère

• Université Lyon 1 Claude Bernard

  Villeurbanne 2012 - 2013 Master's degree in "Organic synthesis and chemistry of bioactive molecules"
  
  Double diploma in collaboration with my engineer diploma of CPE Lyon.
  Intensive courses about all the methods used to synthesize and analyse complex bioactive molecules and polymers.
  

• CPE Lyon

  Villeurbanne 2012 - 2013 Engineer degree
  
  Chimie organique - Double diploma in collaboration with "Université Lyon 1"
  Courses followed at CPE Lyon this year were Management, Human ressources, Languages.

• CPE Lyon

  Villeurbanne 2009 - 2013 Ingénieur en chimie et génie des procédés

Réseau

• Anne PAILLARD-BRUNET

• Benjamin FLORIO

• Camille LENZI

• Chloé MONTES

• Clément PIQUE

• Marine LEJEUNE

• Mathilde MOYNE

• Nesrine OUADAH

• Ninon CRETIN