Menu

Bertrand BIRLINGER

RUEIL MALMAISON

En résumé

I have deep experience in a broad field of lab techniques including cell culture, in vitro assays with cold and radioactive compounds, HPLC, LC-MS, RT-PCR, and enzyme kinetics. I independently perform experiments and procedures. I like to set up new methods and to improve existing ones, also with liquid handling robots wherever possible. I am responsible for the planning, organization, evaluation, documentation and reporting of experiments of a high degree of complexity. I’m a member of the Health Safety and Environmental (HSE) department and a local Biosafety Officer (BSO) in archiving Health Authorities inspections.

Entreprises

  • Novartis - Scientist at Novartis Institutes for BioMedical Research (NIBR)

    RUEIL MALMAISON 1987 - maintenant Individual Tasks:
    • Independently perform experiments and procedures with high degree of complexity
    • Develop new and innovative experiments based on publications, adapt to internal needs and requirements
    • Demonstrating increasing expertise with a wide range of techniques (HPLC, RT-PCR, UPLC-MS)
    • Provide independent interpretation of results, evaluate data, plan follow-up and contribute to the design of next experiment
    • Recognize problems and provide solutions
    • Analyze and interpret data from different sources and draw relevant conclusions
    • represent lab at meetings.
    • Contribute to report writing.
    • Mentoring of students.
    • Demonstrate flexibility in adapting methods/skills according to evolving project priorities
    • High knowledge in special discipline (e.g., in vitro experiments, cell culture and spectrometry)
    • Operate and perform routine maintenance of instruments and evaluate new equipment needs
    • Demonstrate an excellent understanding and knowledge of laboratory tools, techniques, methods and underlying principles
    • Conduct activities according to the appropriate SOP and guidelines
    • Conduct activities in compliance with Novartis safety, waste disposal and other regulatory guidelines

    Main duties in current position:
    • Plan, perform, optimize and analyze DMPK in vitro studies
    • measurement of various enzymatic activities by spectrophotometry, HPLC, MS and radioassays
    • Highthroughput method to determine IC50, Ki, Mechanism-based enzyme inactivation
    • Independent determination, calculation and interpretation of kinetic parameters (Sigma Plot, GraFit)
    • Real Time PCR for induction screening (PCR Real-Time AB 7900HT-MagMax-96 Total RNA Isolation Kit)
    • extraction and purification of metabolites by SPE, HPLC and UPLC-MS (Waters Xevo-TQ-S)
    • elaboration of microplate format assays on different robotic systems (e.g., Viaflo96, epMotion)
    • Cell culture assay (e.g.,hepatocytes or cell line system)
    • organisation and maintenance of the cell culture laboratory.

Formations

Réseau

Annuaire des membres :