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BRUEBACH

En résumé

Mes compétences :
Antibiotics
Anti-infectives
Infectious Diseases
Drug Discovery
organizational skills
medical microbiology
Biophysics
Biochemistry
Triage
SAR analysis
Responsible for lead finding
Responsible for defining project strategy
Development of screening and secondary assays

Entreprises

  • Basilea Pharmaceutica International - Project Manager & Senior Research Scientist

    2000 - 2016 * Project Leader for anti-infective drug discovery projects

    * Responsible for defining project strategy, securing intellectual property
    and new project proposals.
    * Responsible for lead finding and optimization, comprising full in vitro
    characterization (target inhibition, in vitro susceptibility, time-kills kinetics,
    resistance development and stability, protein binding, cytotoxicity
    assay...) and in vivo profiling to clinical candidate selection.
    * Managing a cross functional team, including coordination of chemistry,
    biology and pharmacology activities.
    * Identification and integration of external resources (CRO and academic).
    * Development of screening and secondary assays ;
    * SAR analysis with active contributions to the chemistry plans. ;
    * Whole cell phenotypic and target-based screens triage. ;
    * Mechanisms of antibacterial activity and resistance elucidation.

    * Biochemist expert providing support to research projects in the fields of antiinfective, anti-inflammatory drugs and oncology, including analysis of
    ligand binding and target inhibition mechanisms

    * Excellent biochemistry, enzymology and structural analysis expertise.
    * Skilled in protein purification and characterization, HPLC, spectroscopic
    measurements, radiolabeled and fluorescent thermal shift assays.
    Specialist in Hummel Dreyer SEC Multi-Angle static Light Scattering (MALS).
    * Expert in Isothermal Titration Calorimetry (ITC) and Differential Scanning
    Calorimetry (DSC).
  • F. Hoffmann-La Roche - Research Scientist

    1999 - 2000 Diseases Department
    * Leading a specialised laboratory performing ligand binding studies with
    lead compounds from the infectious disease department. Support of
    chemical optimisation for anti-infective research programs.
  • F. Hoffmann-La Roche - Post-Doctoral

    1997 - 1999 Post-Doctoral Position, Pharma Research Preclinical, Infectious
    Diseases Department with Prof. M. Page
    * Establishment and validation of microcalorimetry as a routine method for
    characterising drug/target interactions in support of research programs.

Formations

  • University Of London (London)

    London 1993 - 1997 Doctor of Philosophy in Medical Microbiology

    St Bartholomew's and the Royal London School of
    Medicine and Dentistry (
    PhD, Department of Medical Microbiology with Prof. D. Livermore.
    * Study of extended-spectrum ß-lactamases from Pseudomonas aeruginosa
    isolates collected in Turkey.
  • Université Des Sciences Et Technologies De Lille (Lille I)

    Lille 1991 - 1992 Diplôme d'étude approfondies (DEA, Post-graduate degree)


  • Université Lille I - Sciences Et Technologies

    Villeneuve D'Ascq 1989 - 1990 Maitrise de Biochimie

Réseau

Pas de contact professionnel