Ghislain GILLARD

En résumé

Entreprises

• MRC Laboratory of Molecular Biology - Post-Doctoral Fellow

  2017 - maintenant

• Institut de Génétique et de Développement de Rennes - CNRS UMR 6290 - Grégoire Michaux's Team - PhD Student

  2012 - 2016 I have been a PhD student in the team of Dr Grégoire Michaux, at the IGDR in Rennes for four years. I have been first interested in the mechanisms enabling eptithelial cells to polarize their plasma membrane into two distinct domains (e.g. an apical one and a basolateral one) separated by junctions. Such an organization requires a proper targeting of proteins and lipids toward the correct domain of the plasma membrane and is essential for proper development, since many diseases and cancers arise from a loss of polarization. The project of my PhD have consisted in the idenfication of new sorting mechanisms enabling such a fascinating organization. In particular, I have been interested in the mechanisms involved in the sorting of E-cadherin, an essential cell-cell adhesion molecule, in epidermal cells, using the nematode Caenorhabditis elegans as a model organism. This work has led to a publication (Gillard et al., Development, 142, 1684).
  On the other hand I decided to focus on morphogenesis, this fascinating process enabling an organ or even a whole organism to acquire its final shape. I identified a new signalling pathway involving three different tissues, from muscles to epidermis, in order to promote the coordinated morphogenesis of the whole organism. This work is currently submitted.

• Institut de Biologie du Développement de Marseille Luminy - CNRS UMR 7288 - André Le Bivic's Team - Internship Student

  2012 - 2012 Deciphering AP-1 function in apical sorting in Caco-2 epithelial cells
  
  - Cell Culture
  - Biochemistry
  - Immunostaining
  - siRNA
  - Confocal microscopy

• Institut de Génétique et de Développement de Rennes - CNRS UMR 6290 - Grégoire Michaux's Team - Internship Student

  2011 - 2011 an RNAi screen to identify sorting mechanisms involved in the basolateral localisation of SLCF-1 in the C. elegans intestine
  
  - RNAi
  - Confocal microscopy

• Pontchaillou Hospital - Virology lab - Internship Student

  2009 - 2009 Culture of Hepatitis B virus on modified astrocytes
  
  - Cell culture
  - Molecular Biology

• CSB Football - Football Trainer

  2003 - 2010 Training and coaching of young players from 6 to 17 years old. Federal certificate ("Initiateur 1") obtained in 2009

Formations

• Université Rennes 1

  Rennes 2010 - 2012 Master's degree, Molecular et Cellular Sciences, First class honours

• Université Rennes 1

  Rennes 2009 - 2010 Bachelor's degree, Biochemistry and Molecular Biology

• Institut Universitaire De Technologie

  Brest 2007 - 2009 Bachelor of Technology (BTech)

Réseau

• Claudia JOUANNIC

• Emmanuel JAMES

• Hélène BOUVRAIS

• Margaux BOULY

• Mathieu COUSTANS

• Matthieu VALLEE

• Sandrine FAYARD

• Serge Patrick MONKON LL

• Yann LE MENE