Mes compétences :
Developmental Biology
Gateway
Adaptability
ImageJ
Oral and written communication skills
Confocal microscopy
Genetics
Resilience
Research projects
RNAi
Entreprises
MRC Laboratory of Molecular Biology
- Post-Doctoral Fellow
2017 - maintenant
Institut de Génétique et de Développement de Rennes - CNRS UMR 6290 - Grégoire Michaux's Team
- PhD Student
2012 - 2016I have been a PhD student in the team of Dr Grégoire Michaux, at the IGDR in Rennes for four years. I have been first interested in the mechanisms enabling eptithelial cells to polarize their plasma membrane into two distinct domains (e.g. an apical one and a basolateral one) separated by junctions. Such an organization requires a proper targeting of proteins and lipids toward the correct domain of the plasma membrane and is essential for proper development, since many diseases and cancers arise from a loss of polarization. The project of my PhD have consisted in the idenfication of new sorting mechanisms enabling such a fascinating organization. In particular, I have been interested in the mechanisms involved in the sorting of E-cadherin, an essential cell-cell adhesion molecule, in epidermal cells, using the nematode Caenorhabditis elegans as a model organism. This work has led to a publication (Gillard et al., Development, 142, 1684).
On the other hand I decided to focus on morphogenesis, this fascinating process enabling an organ or even a whole organism to acquire its final shape. I identified a new signalling pathway involving three different tissues, from muscles to epidermis, in order to promote the coordinated morphogenesis of the whole organism. This work is currently submitted.
Institut de Biologie du Développement de Marseille Luminy - CNRS UMR 7288 - André Le Bivic's Team
- Internship Student
2012 - 2012Deciphering AP-1 function in apical sorting in Caco-2 epithelial cells
