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Julien BARC

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En résumé

During my PhD, I have received training in the field of cardiovascular genetics.This led to high-impact publications including one paper at Nature Genetics (IP: 36.4), a top-tier journal in genetics, at Journal of the American College of Cardiology (IP: 14.3),JACC has the second highest impact factor of cardiovascular journals.
During my current post-doctoral employment in Amsterdam, as well as during a short stay at the KULeuven (Prof. J. Vermeesch) I have furthered my experience with state-of-the-art genetic technologies including next generation/exome sequencing and GWAS.

Projects during my Post-doc:
Project 1: Development of next generation sequencing (NGS) technology, strategy and analysis in the group.

- Development of pipeline analysis for NGS including variant annotation, public exome/genome databases.
- Identification of mutation in CALM1 (by exome sequencing), encoding calmodulin, as a cause of familial idiopathic ventricular fibrillation in childhood and adolescence (Published in JACC).
- Exome sequencing on an Irish family with Brugada Syndrome uncovering a novel locus for the disorder.
- Development (first world-wide user) and application of a new capturing technology (Haloplex, Agilent) enabling capture and sequencing of a panel of 150 cardiac genes at once.


Project 2: Leading role in a pilot genome-wide association study (GWAS) on a rare cardiac arrhythmia: the Brugada Syndrome ( published in Nature Genetics).

- Collection and harmonization of ECG and clinical data from 13 clinical centers in Europe, US and Japan.
- Statistical analysis
- Validation of genetic findings, functional studies, manuscript writing.

Mes compétences :
Nouvelle génération de séquençage
Etude d'association génome entier
cardiovasculaire
Nouvelles technologies
Génétique

Entreprises

  • Heart Failure Research Center, Academic Medical Center, University of Amsterdam - Postdoctoral Investigator

    2010 - maintenant * Prize Edouard Coraboeuf (2014)
    * 2nd prize of the JESFC young investigator award: “Complex Brugada syndrome inheritance in a family harbouring compound SCN5A and CACNA1C mutations”. JESFC 2014
    * Van Gogh programme (2012 and 2013)
    * European Society of Cardiology research grant (2011)
    * Fondation Leducq Fellowship: Leducq Network: Alliance Against Sudden Death (2009)
    * 1st prize: Grant from the French Society of Cardiology (2008);
    * Member of the European society of Human Genetics; Member of the Council on Basic Cardiovascular Sciences, American heart Association; Member of the Cardiac Electrophysiology Society; Member of the Working Group on Cardiac Cellular Electrophysiology, European Society of Cardiology

  • Inserm/CNRS UMR 915, institut du thorax, Nantes, France - PhD student

    2006 - 2010 Thesis: Genetics of ventricular repolarization defects: new concepts
    (Supervisor : Dr. Jean-Jacques Schott)
    * Project 1: Genotype-Phenotype studies and gene discovery in Brugada Syndrome
    (Circ. Cardiovasc. Genet. 2009).

    * Project 2: Identification of copy number variation in genes associated with the Long QT Syndrome as a cause of the disorder: application in DNA diagnostics (JACC, 2011).

    * Project 3: Exome sequencing identifying KLHL3 mutations as a cause of familial hyperkalemic hypertension by impairing ion transport in the distal nephron (Nat. Genet., 2012).

Formations

Pas de formation renseignée

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