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Madani RACHID

MARSEILLE

En résumé

Mes compétences :
Infectious Diseases
HPLC
ELISA
Early development
UPLC
Pharmacokinetics
Microsoft Windows
Mass Spectrometry
LC-MS
Drying assay development
Bioanalytic development
Phoenix Winonlin
Monolix
Adapt5

Entreprises

  • Genoscience Pharma - Preclinical Project Leader

    2017 - maintenant Study management and monitoring (in vivo Pharmacology, DMPK, Tox)
    Presentation of results
    Set up of DMPK assays
    IND, IB, IMPD filling
    Follow up of CRO's
    Define exploratory and regulatory drug development strategies
    Screen, select and optimize lead compounds
  • Citoxlab - Study director in DMPK

    Évreux 2014 - 2017 Act as study director in DMPK (in vivo/ in vitro) for pharmaceutics/chemitry/cosmetics groups in a GLP enviromenment
    DMPK:
    - Non-compartmental analysis
    - ADME studies (radiolabeled compounds)
    - Skin permeation assays (Franz cells)
    - Protein Binding (RED)
    - CYP inhibition
    - CYP induction
    - Metabolite Identification (in vivo/ in vitro)
    - Metabolic stability (in vitro)
    Manage sub-contrators for in-vitro experiments
    Prepare study plans, reports and communication with clients
  • University of Pittsburgh Cancer Institute - Pharmacocinéticien

    2014 - 2014 Pop PK using Adapt5 et Monolix in clinical trials
    Cytidine deaminase activity assay
    Protéines binding assay by Rapid Equilibrium Dialysis
    LC-MS/MS assay development and validation (FDA)
    Met ID of a PUMA inhibitor using LC-MS/MS
  • Firalis - Stagiaire

    2013 - 2013 Developpement of a lyophilisation method for recombinant material
    Developpement of quality control for 96 wells plate coating (immunoassay)
    ELISA
    SDS-PAGE
    Assay development
  • APHM - Stagiaire pk

    Marseille 2012 - 2012 Développement analytique (HPLC-UV)
    Extraction liquide/liquide, solide/liquide
    Validation de méthode (dosage de la quinidine dans du plasma)
    Rédaction d'un poster

Formations

  • Universities Of Aix-Marseille And Limoges

    Marseille 2008 - 2014 Doctor of Pharmacy

    Mention Industry, University of Aix-Marseille and Limoges,
    * 6th year: Master II (research) degree of Pharmacokinetics: Experimental Pharmacokinetics, Clinical Pharmacokinetics, Modeling and Therapeutic Drugs Chemistry.
    Thesis subject: ``PUMA (p53 Up-Regulated Modulator of Apoptosis): interests, early development and métabolic study of the hit 7''
    * 5th year: University Diploma of Anima
  • University Of Sciences Of Luminy

    Marseille 2007 - 2008 DEUG (two years diploma)

    focus: Biochemistry, Molecular Biology

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