Madani RACHID

En résumé

Entreprises

• Genoscience Pharma - Preclinical Project Leader

  2017 - maintenant Study management and monitoring (in vivo Pharmacology, DMPK, Tox)
  Presentation of results
  Set up of DMPK assays
  IND, IB, IMPD filling
  Follow up of CRO's
  Define exploratory and regulatory drug development strategies
  Screen, select and optimize lead compounds

• Citoxlab - Study director in DMPK

  Évreux 2014 - 2017 Act as study director in DMPK (in vivo/ in vitro) for pharmaceutics/chemitry/cosmetics groups in a GLP enviromenment
  DMPK:
  - Non-compartmental analysis
  - ADME studies (radiolabeled compounds)
  - Skin permeation assays (Franz cells)
  - Protein Binding (RED)
  - CYP inhibition
  - CYP induction
  - Metabolite Identification (in vivo/ in vitro)
  - Metabolic stability (in vitro)
  Manage sub-contrators for in-vitro experiments
  Prepare study plans, reports and communication with clients

• University of Pittsburgh Cancer Institute - Pharmacocinéticien

  2014 - 2014 Pop PK using Adapt5 et Monolix in clinical trials
  Cytidine deaminase activity assay
  Protéines binding assay by Rapid Equilibrium Dialysis
  LC-MS/MS assay development and validation (FDA)
  Met ID of a PUMA inhibitor using LC-MS/MS

• Firalis - Stagiaire

  2013 - 2013 Developpement of a lyophilisation method for recombinant material
  Developpement of quality control for 96 wells plate coating (immunoassay)
  ELISA
  SDS-PAGE
  Assay development

• APHM - Stagiaire pk

  Marseille 2012 - 2012 Développement analytique (HPLC-UV)
  Extraction liquide/liquide, solide/liquide
  Validation de méthode (dosage de la quinidine dans du plasma)
  Rédaction d'un poster

Formations

• Universities Of Aix-Marseille And Limoges

  Marseille 2008 - 2014 Doctor of Pharmacy
  
  Mention Industry, University of Aix-Marseille and Limoges,
  * 6th year: Master II (research) degree of Pharmacokinetics: Experimental Pharmacokinetics, Clinical Pharmacokinetics, Modeling and Therapeutic Drugs Chemistry.
  Thesis subject: ``PUMA (p53 Up-Regulated Modulator of Apoptosis): interests, early development and métabolic study of the hit 7''
  * 5th year: University Diploma of Anima

• University Of Sciences Of Luminy

  Marseille 2007 - 2008 DEUG (two years diploma)
  
  focus: Biochemistry, Molecular Biology

Réseau

• Aurélie QUENTIN CHUPIN

• Barbara DUBANCHET

• Clémentine CHALMEY

• Corinne CHAIMBAULT

• Philippe GARCONNET

• Philippe PERSIL

• Sébastien LENDORMY