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Euroscreen
- Research Assistant
2009 - maintenant
-Realization and interpretation of in vitro testing for ADME and Tox characterization : Intestinal permeability (Caco-2 cells, IAM), in vitro Metabolism, Induction/Inhibition of Enzyme involved in metabolism, Plasma Protein Binding, Plasma Stability, Cytotoxicity
-Cell culture activities
-Analytical Support (UPLC-MS)
-Deorphanization : extracts preparation from animal tissues – HPLC separation
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Baxter
- Coordinator for stability studies
Maurepas
2007 - 2009
Study Director of stability study projects:
-Participation in the planning and implementation of protocols
-Protocols and reports writing
-Programation in LIMS
-Review of stability results: trend, statistical evaluation, anticipation of future issue
-Work performed in GLP/GMP environment
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Eli Lilly
- Scientist
neuilly sur seine
2004 - 2007
- Leadership of the absorption group : planning, experimental protocol design, conduct of experiments, scientific interpretation of the results, reports writing, interactions with internal clients
- in vitro absorption studies (Caco-2 cells) :
- global support for Lead Optimization (LO) and post-Candidate Selection phases (bi-directional screening and solubility-permeability assessment)
- mechanistic studies
- improvement of model and development of new screens
- robotic system programming
- Experience with Biopharmaceutics Classification System (BCS)
- Analytical support (LC-MS)
- Cell culture activities, use of a robotic system
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Eli Lilly
- Scientist, Associate Analyst
neuilly sur seine
2000 - 2003
- Technology of irradiation sterilization: E-beam and gamma - Irradiation of pharmaceuticals: Set up and improvement of irradiation conditions on small and large molecules
- Techniques of dosimety
- Analytical support : implement and challenge analytical method, development of new method (HPLC/ UV, DSC,TGA, hot-stage microscope) in order to verify the stability of the molecules submitted to ionizing radiation
- Formulation support for samples preparation : freeze-drying, blending, solution
- Support to the project manager : design of studies, planning of activities and resources, collaboration with contract lab (irradiation and sterility testing), communication and presentation of results, reports writing
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Eli Lilly
- Formulation assistant
neuilly sur seine
1999 - 2000
- Development of formulations for pre-clinical studies
- Preparation of samples for toxicology and drug metabolism studies according to GLP
