Mes compétences :
Screening
Molecular biology
Chef de projet
Data analysis
Supervision of colleagues and apprentices
Daily management
Project coordination
Oncology
Hepatitis C
Drug Discovery
Dermatology
Entreprises
Novartis
- Associate project manager
RUEIL MALMAISON 2015 - maintenant* Strategic definition of low molecular weight identification projects :
- Target validation (big picture, literature, assay definition)
- Screening technology definition (state of the art screening readers and technologies, innovation)
- Screening campaign assay development (full automation and miniaturization)
- Hit identification (data mining, image analysis)
- Hit-to-lead designation (teamwork, collaboration, leadership)
NOVARTIS Pharma
- Scientist II
2009 - 2015* Management of screening campaigns to identify active compounds related to diverse pathologies * Labhead deputy for the operational and daily management ;
* Development of several high content screening assays using stem and primary cells, using front runner imagers such as Opera or CV7000
* Part of the team in charge of the implementation of the new automated screening platform STEP 2 designed for the automation of 2 Hammamatsu FDSS 7000
* Development of a new cellular imaging technic for C5a receptor used by the project team as a basis to develop PK/PD assays for CSP nomination (project is now a PoC)
* Identification of the first positive allosteric modulator of PGI2 receptor which has driven to several patents
* Evaluation of BacMam technology (1 month Mini sabbatical in Novartis Horsham Research Center (England)) and implementation of the technology in Basel, successfully used on primary cells
* Coach of technicians and apprentice: participate to the recruitment process, education and evaluation, operational guidance
NOVARTIS Pharma
- Scientist I
2003 - 2009* Management of 10 to 15 HTS campaigns: organization, implementation and cost follow up ;
* Project coordination: planning definition in term of needs, implementation of assays, data analysis and data presenting at project team meeting, coaching of 2 apprentices ;
* Presentation of results on Hepatitis C project at international conference MIPTEC in Basel
* Publication of an article about troubleshooting of Homogeneous Time Resolved Fluorescence in Assay and Drug Development magazine
* Evaluation of new biochemical and cell based label free technologies (3 months mini sabbatical in Novartis Emeryville Research Center (California))
NOVARTIS Pharma
- Scientific Associate
2001 - 2003* Management of several cellular and biochemical HTS campaigns: data analysis, presentation of results to my supervisor. Find out of the ability of RBL cells to be primed by ADP, which increase the calcium signal of GPCRs
* Assay automation: development and evaluation of new innovating technologies, set up of new automated systems. Implementation of the first 1536 protein-protein interaction HTS campaign using Alphascreen
NOVARTIS
- Assistant de recherche
RUEIL MALMAISON 2000 - 2000CDD en temps qu'assistant de recherche au sein de l'unité d'oncolgie de Novartis :
- Etude de l'interaction p53-mdm2-p19ARF et dévelopement d'un essai de criblage phénotypique
NOVARTIS
- Research Associate
RUEIL MALMAISON 2000 - 2000* Set up of an HTS adaptable screening phenotypic method by fluorescence transfer to study the pathway p53 - hdm2 - p14ARF. DNA and RNA purification, protein analysis
Pierre FABRE
- Research Associate
Castres1998 - 1999* Set up of a new method to extract native collagen from fish's skin
