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Simon DUJARDIN

LILLE

En résumé

I am currently as Postdoctoral research Fellow in the team leaded by Prof Bradley T. Hyman in the Massachusetts Alzheimer's disease Research Center depending on the Harvard Medical School and Massachusetts General Hospital in Boston, USA.
Previously, I did my PhD in the french institute for medical research (Inserm). I am also engineer in biotechnologies, graduated in 2012 from Sup'biotech Paris.
My PhD took place in Lille (Inserm UMR-S 1172, "Alzheimer & Tauopathies") and was focused on the understanding and modelisation of the Tauopathies including Alzheimer's disease. In particular we tried to settle how Tau pathology is spreading through the brain.

During my studies, I did a lot of research internships, and particularly in the University of Oxford, the Cleveland Clinic, the "Institut de Biologie de Lille" and also in a pharmaceutical start-up: Alzprotect. During these great experiences, I gain a large experience in biotechnologies with technical skills in particular in genetic and cell culture. But I also acquire notions like the team work or the project management. In addition, I did two of these training periods in english speaking countries and so I am a fluent english speaker.

My school, Sup'biotech Paris, is located in Villejuif, next to Paris.
This training course is very innovative because very organized in projects and next to the company world. Furthermore we have a double course: a scientific background in biotechnologies and a competence in project management and marketing. I choose the speciality Research and development. During my third year, I passed my bachelor in biotechnology science.

Mes compétences :
Biologie
Biotechnologies
Business intelligence
Cellular Biology
Biologie moléculaire
Chemistry
Informatics
Gestion de projet

Entreprises

  • Harvard Medical School - Mass. General Hospital - Postdoctoral Research Fellow

    2016 - maintenant I am currently working as a post-doctoral research fellow in the laboratory leaded by Pr. Bradley T. Hyman in the Massachusetts General Hospital / Harvard Medical School performing research on the pathophysiological mechanisms of Alzheimer's disease.

  • Inserm U837 - PhD student

    2011 - 2015 I did my PhD research in the Inserm UMR837 EQ1, "Alzheimer & Tauopathies"
    My PhD project was dedicated to the study of the mecanisms allowing the neuron-to-neuron spreading of neurofibrillary degeneration in Tauopathies. This work was based on 3 major objectives : 1) How and in which form Tau is transferring from cell-to-cell 2) What are the signals inducing or potentiating Tau secretion? 3) Is it a correlation between pathologic phase and secreted forms of Tau in human CSF?

  • Alzprotect - Project leader assistant

    Loos 2010 - 2011 At Alzprotect, I developed a molecular biology platform. I also developed and lead a project in order to characterize the effect of a pharmaceutical component on gene expression.

  • Alzprotect - Project manager assistant

    Loos 2010 - 2011 At Alzprotect, I developed a molecular biology platform. I also developed and lead a project in order to characterize a pharmaceutical component.

  • Cleveland clinic, Taussig Cancer Institute - Research internship

    2010 - 2010 I worked on the newest whole genome scanning technologies, as applied to cancer association studies and karyotyping of somatic lesions.
    I handled large data sets and subject them to bioanalytic tools, including copy number analyzer, genome typing tools and allelic imbalance. Special emphasis is set on understanding of the biological relevance of the bioinformatic applications.

    Publication:
    23 Février 2011; Blood
    Makishima H, Jankowska AM, McDevitt MA, O'Keefe C, Dujardin S, Cazzolli H, Przychodzen B, Prince C, Nicoll J, Siddaiah H, Shaik M, Szpurka H, Hsi E, Advani A, Paquette R, Maciejewski JP
    "CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia."

  • CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France - Research internship

    2009 - 2009 I worked in the Genomics and Molecular Physiology of Metabolic Diseases laboratory. During this internship, I used the Bioluminescence and Resonance Energy Transfer (BRET) technique (Bacart J et al. The BRET technology and its application to screening assays. Biotechnol J. 2008 Mar;3(3):311-24.). This technique allow me to practice all the cell culture techniques and the molecular biology techniques

  • Oxford University - Research internship

    2007 - 2007 During this internship, I did a lot of experiment in genetic like :
    - PCR and gel electrophoresis
    - DNA sequencing
    - RNA and DNA extraction and quality evaluation
    - Gene expression profiling using Affymetrix microarrays
    - Real time quantitative PCR (Taqman)

    That was very interesting for me because it was the first long time in a lab and I took advantage of this internship to improve my english. Furthermore, I learned a lot about genetic and about the new techniques of microarrays.

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