UMR 8076 - BioCIS
- Doctorant
2007 - maintenant
UMR 8076 - BioCIS : Laboratoire de Chime Thérapeutique du Pr. J.-D. BRION et du DR CNRS M. ALAMI
Doctorant de l'Université Paris 11 Sud
Synthèse d'inhibiteurs de la protéine-chaperon hsp90, potentiels anti-cancéreux.
Title : “Synthesis of purine derivatives as potential hsp90 inhibitors”
Publications :
6. Sahnoun S.; Messaoudi, S; Brion, J.-D.; Alami, M. manuscript under preparation 2011.
5. Sahnoun S., Messaoudi S., Brion J.-D., Alami M. “Palladium-catalyzed direct benzylation of xanthines” ChemCatChem 2011, doi: 10.1002/cctc.201000439.
4. Sahnoun S., Messaoudi S., Brion J.-D., Alami M. “Selective C-H arylation and alkenylation of free-(NH2) adenines and related heterocycles : Rapid access to potent hsp90 inhibitors” Abstracts of Papers 2010, 240th ACS National Meeting, Boston, MA, United States, August 22-26, ORGN-470.
3. Sahnoun S., Messaoudi S., Brion J.-D., Alami M. “Pd/Cu-catalyzed direct alkenylation of azole heterocycles with alkenyl halides” Eur. J. Org. Chem. 2010, 6097-6102. (Highlighted article in ChemInform 2011, 42, doi: 10.1002/chin.201109047)
2. Sahnoun S.; Messaoudi, S; Brion, J.-D.; Alami, M. “A site selective C-H arylation of free-(NH2) adenines with aryl chlorides: application to the synthesis of 6,8-disubstituted adenines”. Org. Biomol. Chem. 2009, 7, 4271-4278. (Highlighted and selected article in ChemInform 2010, 41, doi: 10.1002/chin.201008176)
1. Sahnoun S.; Messaoudi, S; Peyrat, J.-F.; Brion, J.-D.; Alami, M. “Microwave-assisted Pd(OH)2-catalyzed direct C-H arylation of free-(NH2) adenines with aryl halides”. Tetrahedron Lett. 2008, 49, 7279-7283.(Highlighted in Org. Chem. Highlights 2008, November 15. see http://www.organic-chemistry.org/Highlights/2008/15November.shtm / Highlighted and selected article in ChemInform 2009, 40, doi: 10.1002/chin.200912173)
Awards & Contributions :
- Best Oral Communication Award at the Young Research Fellow Meeting 2010, from the French Medicinal Chemistry Society (SCT), February 5th, 2010, Paris, France.
- Invited as Junior Member of the Scientific Committee of the Young Research Fellow Meeting 2011, French Medicinal Chemistry Society, February 4th, 2011, Paris, France.
