Xavier LECLERC, PHD

En résumé

Entreprises

• Clean Cells - Geneticist - Head of Gene Therapy & R&D Project Manager

  Boufféré 2015 - maintenant QUALITY CONTROL for GENE THERAPY, GENOME ENGINEERING and BIOPRODUCTION
  
  Management of activities dedicated to viral vectors quality control
  
  - Scientific projects steering
  - Viral vectors Quality Control
  - Development and validation of analytical assays according to EP, USP and ICH and in compliance with GLP/GMP
  - Viral vectors bioproduction
  - Reporting to scientific committees
  - Assistance to Business Unit

• Tennis Fauteuil Riez Océan Association (TFRO) - Member of the Administration Committee

  2014 - maintenant Member of Tennis Fauteuil Riez Océan Association (TFRO) at Saint Hilaire de Riez (France)
  
  TFRO key figures:
  
  - Tennis Handisport promotion
  - Organisation of Tennis Handisport tournaments (France championships 2014 and 2015, Open tournaments)
  - Awards: Champion of France Team (2014, 2015 and 2016)
  - Player: Stéphane Houdet (rank: world n°1)

• Tennis Club Riez Océan Association (TCRO) - Chief Administration Officier

  2014 - maintenant CAO at Tennis Club Riez Océan Association (TCRO) at Saint Hilaire de Riez (France)
  
  TCRO key figures:
  
  - Practice and teaching tennis (leisure and competition)
  - 3 full-time employees and seasonal/initiators, over 200 licensees
  - Open tournaments organisation

• Institute of Biotherapies (in partnership with Cellectis) - Project Leader

  2009 - 2014 GENOME ENGINEERING, GENE THERAPY, VECTOROLOGY & BIOPRODUCTION
  - Scientific projects steering
  - Meganuclease-driven genome engineering
  - Development of innovative gene expression systems for the characterisation of engineered nucleases
  - Duchenne Muscular Dystrophy (DMD) biology
  - Development of optimized production processes for lentiviral vectors biomanufacturing
  - Development of de novo purification processes for new lentiviral vectors pseudotypes biomanufacturing
  - Development of a new lentiviral vector pseudotype for the generation of Sf9 producer cell lines for the large-scale biomanufacturing of AAV-based vectors (baculovirus system)
  - Management of a lentiviral vector production unit (BSL2)
  - Development of analytical assays
  - Logistical and operational management
  - Staff management and training activities
  - Budget and documentation management
  - Reporting to scientific committees
  - Communication and teaching activities
  - Scientific intelligence
  

• Higher Studies Practical School (Ecole Pratique des Hautes Etudes, EPHE) - Paris-Sorbonne University - Invited Lecturer

  2008 - 2015 - Human genetics courses - Genome engineering, gene and cell therapies (2nd year of master degree)
  

• Généthon - PhD Student

  Ivry 2004 - 2008 Evaluation and optimization of gene correction strategies
  Thesis director: Dr Olivier Danos

• University of Versailles - Assistant Lecturer (Instructorship)

  2004 - 2007 Courses: Molecular and cell biology, formal and fundamental genetics (BSc level)
  

• Généthon - MS Student

  Ivry 2002 - 2003 QC & Analytical Development in Dr Muriel Audit laboratory (henceforth Genosafe)
  
  - Development and validation of a method for the quantification of integrated lentiviral vector genomes and measurement of transgene expression levels using RT-qPCR assays

Formations

• UNIVERSITY PIERRE ET MARIE CURIE, PARIS VI

  Paris 2010 - 2011 Post-graduate Diploma - Patents, intellectual property, technology transfer, biotechnology and biomedical innovation
  
  University Degree - Exploitation of applied research and biomedical innovation
  Theme of the thesis: Genome surgery and custom-made site-specific nucleases
  Graduated with honours

• University Of Paris-Saclay

  Evry 2004 - 2008 PhD program in Genetics
  
  Thesis director: Dr Olivier Danos
  Graduated with highest honours and unanimous jury congratulations

• Faculty Of Pharmaceutical And Biological Sciences - University Paris V - René Descartes

  Paris 2002 - 2003 Advanced Master Degree - Diplôme d’Études Supérieures Spécialisées (DESS), Quality control and quality assurance for gene and cell therapy products and proceedings
  
  Graduated with honours
  

• University Of Rouen

  Rouen 2001 - 2002 Neurosciences courses

Réseau

• Bahia CHERIFI

• Camille RABU

• Cédric TALBOT

• Guillaume PRÉCIGOUT

• Isabelle STUART

• Marie SAND

• Nicolas LAROUDIE

• Severine LEROY

• Stéphane BAYLE

• Vasileios GEORGAKAKOS