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Alexandra LESPAGNOL

RENNES

En résumé

PUBLICATIONS

Reciprocal repression between P53 and TCTP.
Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, Colaluca I, Viale G, Rodrigues-Ferreira S, Wynendaele J, Chaloin O, Hoebeke J, Marine JC, Di Fiore PP, Telerman A.
Nature Medecine, 2012

Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A.
Cell Death and Differenciation. 2008

TCTP protects from apoptotic cell death by antagonizing bax function.
Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A.
Cell Death and Differenciation. 2008

Translationally controlled tumor protein is a target of tumor reversion.
Tuynder M, Fiucci G, Prieur S, Lespagnol A, Géant A, Beaucourt S, Duflaut D, Besse S, Susini L, Cavarelli J, Moras D, Amson R, Telerman A.
Proc Natl Acad Sci U S A. 2004.

Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.
Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Géant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A.
Proc Natl Acad Sci U S A. 2004

Genomic organization and expression of mouse Tpt1 gene.
Fiucci G, Lespagnol A, Stumptner-Cuvelette P, Beaucourt S, Duflaut D, Susini L, Amson R, Telerman A.
Genomics. 2003

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.
Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A.
Proc Natl Acad Sci U S A. 2003

Entreprises

  • Laboratoire de Génétique Somatique des Cancers - Responsable technique

    2010 - maintenant
  • Laboratoire de Biologie et Pharmacologie Appliquée (LBPA), Ecole Normale Supérieure (ENS) - Chercheur

    2007 - 2010
  • Molecular Engines Laboratories (MEL) / Anceris (Filiale de CEREP) - Chercheur Assistant

    2001 - 2007
  • Genset (Centre de recherche) - Technicien supérieur de recherche

    1996 - 2001

Formations

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