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Alexandre PALAGI

  • Pillsbury Winthrop Shaw Pittman LLP
  • Consultant

San Diego

En résumé

After obtaining my MSc in biotechnology and pharmacology from the University of Nice, France and my PhD in genetics from a joint program between Harvard Medical School and the Doctoral School of University of Nice, I am currently working as Technical Consultant within Pillsbury Winthrops Intellectual Property section in San Diego, CA.

Entreprises

  • Pillsbury Winthrop Shaw Pittman LLP - Consultant

    Juridique | San Diego 2021 - maintenant Drafting provisional and non-provisional patents in a wide variety of arts, including biotechnologies, genome engineering, pharmaceuticals, medical devices, mechanical engineering, plant patents, and design patents; effective communication with clients and inventors, foreign associates, and internal support staff, to ensure that robust disclosures are filed and deadlines are met; patent prosecution, including responding to Office Actions, participating in Examiner interviews, maintaining compliance with US and International standards and formalities requirements, RCE filings, continuation and divisional application filings, and requesting corrections to applications and issued patents when required; maintaining active patent portfolio summary documents for clients of all sizes; docket management and project management, with a high degree of organization and attention to detail to ensure that no deadlines are missed and accurate documents are filed; patent and non-patent literature searching using resources such as TotalPatent, Google Patents, Google Scholar, USPTO databases, Espacenet, DesignView, and various international patent office databases, analysis of references for patentability and freedom-to-operate purposes, and participating in patent litigation cases (e.g. expertise in genetics and molecular biology).

  • Mintz Levin - Technical Advisor

    Juridique | 2018 - 2021

  • Dana Farber Cancer Institute - Harvard Medical School - Sponsored researcher

    2013 - 2013 The principal aim of my work was the characterization of the impact on protein-protein interaction of natural non-synonymous Single Nucleotide Polymorphisms (SNPs) present in the human population and/or associated with disease, by "Edgotyping" approach, which entails the systematic determination of the interaction profiles between macromolecules (also called “reference interactome”) followed by the determination of the impact of mutations on known reference interactions (allelic edgotyping). I had to compare the impact of three types of alleles on PPI profiles: natural variants in genes not associated with any disease, natural variants in genes associated with disease, and disease associated mutations. To achieve this goal, a list of genes and their associated variants had to first be generated. The alleles were created by PCR with specifically designed primers, and the PCR products were sequenced to validate that the single nucleotide change had been correctly cloned. The allele bank then inserted into appropriate plasmids for Y2H experiments, and with them an “edgotyping network” could be mapped.

  • Harvard Medical School - Research Intern

    2012 - 2012 The primary aim of this internship was to perform in vivo testing of transcriptional enhancers in Drosophila embryonic mesoderm. From ongoing studies of enhancers in the lab, mutant enhancers were designed that contain mutations in predicted transcription factor binding sites. I was in charge of examining the effect of these transcription factor binding site mutations on the tissue-specific activity of the tested enhancers in whole Drosophila embryos.

  • Venometech - Research Intern

    2011 - 2011 Venom Landscapes : Cartographie peptidique par couplage LC/MS (HPLC/MALDI TOF) de la composition de venins d'araignées mygalomorphes, dans l'optique de la caractérisation de peptides actifs, potentiellement d'intérêt thérapeutique.

  • Polytech' Projets - Président

    2010 - 2012 Président de la Junior Entreprise de l'école d'ingénieurs polytechnique de l'université de Nice Sophia Antipolis.

  • INSERM - U634 - Research Intern

    2009 - 2009 Acquisition de techniques de biologie moléculaire :
    - Southern/Northern/Western blot
    - PCR / qPCR
    - Transformation bacétrienne
    - Purification et concentration ADN
    - Purification protéique

  • BDE Bio - Vice président

    2009 - 2010

Formations

  • Harvard Medical School (Boston)

    Boston 2014 - 2018 PhD

    Activités et associations : Genome engineering, protein-protein interaction network, Highly parallel assays of cis regulatory modules in Drosophila.

    Co-direction PhD between the Bulyk laboratory at Brigham and Women's Hospital and Harvard Medical School, and the Doctoral School of Life Sciences of the University of Nice, France.

    Bulyk lab website: http://the_brain.bwh.harvard.edu

  • Polytech'Nice-Sophia

    Sophia Antipolis 2010 - 2013 Diplôme d'Ingénieur en biotechnologie / Master of Science in Bio-ingineering

    Bio engineering

  • Université Nice Sophia Antipolis

    Nice 2007 - 2010 Bachelor of Science / Licence

    Biology, Genetics, Molecular biology, physiology

  • Lycée Stanislas

    Cannes 2005 - 2007 Bac S - Mention TB

    Baccalaureat Scientifique

Réseau

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