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Servier
- Chef d'études scientifiques
Suresnes
2010 - maintenant
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EMC microcollections GmbH
- R&D Project Leader
2009 - 2010
I was Project Leader in the combinatorial chemistry and custom synthesis department. My missions in the company are to design, develop and synthesize single compounds and focussed libraries (10 to 1000 compounds) based on the hit-to-lead and lead optimisation customer research programs and to lead internal projects (drug discovery programs: modelling, design, synthesis, interpretation of biological data and design of new analogues to improve activity) in different therapeutic areas (mainly metabolic disorders and oncology).medicinal chemistry and custom synthesis
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EMC microcollections GmbH
- Laboratory head - combinatorial chemistry and custom synthesis
2006 - 2009
Design, optimization and synthesis of focused combinatorial libraries for lead structure optimization (heterocycles, natural products, polycycles, oligomers, peptidomimetics using convergent and divergent strategies)” and “custom synthesis (literature research of target compounds, retrosynthetic pathways analysis, feasibility sudy, synthesis, scale-up, purification)”.
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Exotic Materials Institute (Los Angeles, U.S.A.)-Mitsubishi Chemicals (Santa Barbara, U.S.A.).
- Postdoc
2005 - 2006
“Synthesis of micelles and organogels” and “donor fullerene-based active layers in OLEDs”.
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University of California, Los Angeles (U.S.A.)
- Postdoc
2004 - 2005
Total synthesis of Guanacastepene A” and “phosphine catalyzed synthesis of 6-substituted 2-pyrones” (Swiss NSF Postdoctoral Fellowship).
See for example: 10) A Phosphine-Catalyzed Synthesis of 6-Substituted 2-Pyrones: Manifestation of E/Z-isomerism in the Zwitterionic Intermediate, X.-F. Zhu, A.-P. Schaffner, R. C. Li, O. Kwon, Org. Lett., 2005, 7, 2977.
