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Benoît THIBAULT

TOULOUSE

En résumé

Mes compétences :
Expérimentation animale
Enseignement universitaire
Biologie cellulaire
Pharmacologie
Biologie moléculaire
Culture cellulaire
Gestion de projet

Entreprises

  • Cancer Research Center of Toulouse - Post-doctoral Researcher

    2016 - maintenant

  • Cancer Drug Research Laboratory - McGill University (Montreal) - Post-doctoral Researcher

    2014 - 2015 Study of the simultaneous inhibition of c-Met and EGFR on the platinum-resistance induced by mesenchymal stem cells in the ovarian cancer, Cancer Drug Research Laboratory, McGill University (Montréal, Canada)

  • Institut Claudius Regaud - IUCT - Postdoctoral Researcher

    2013 - 2014 Study of an inhibitor of IAP (inhibitor of apoptosis protein), DEBIO 1143, in the ovarian cancer, Debiopharm laboratories (Switzerland) and Institut Claudius Regaud – IUCT (EA 4553, Toulouse, France).
    • Analysis of cytotoxic efficacy of DEBIO 1143 alone or in combination with carboplatin, in vitro and in vivo in ovarian cancer.
    • Study of cell death mechanisms implied.
    • Study of DEBIO 1143 resistance/sensitivity factors.

  • Institut Claudius Regaud - Postdoctoral Researcher

    2013 - 2013 Study of an anti-cancer molecule derivated from the etoposide and linked to a spermin chain (F14512) in the ovarian cancer, Pierre Fabre laboratories (Toulouse, France) and Institut Claudius Regaud (EA 4553, Toulouse, France).
    • Determination of the F14512 cytotoxic efficacy in human ovarian cancer cells in vitro.
    • Analysis of the F14512 capacity to induce apoptosis and senescence in human ovarian cancer cells in vitro.
    • Study of the F14512 anti-tumoral efficacy in murine models of human ovarian cancer cells xenografts.

  • Institut Claudius Regaud - PhD Student

    2009 - 2013 Role of Hospicells in the ovarian cancer progression and diessemination: particular implication of macrophages, under the co-direction of Pr. Bettina Couderc and Pr. Jean-Pierre Delord, Claudius Regaud Institute (EA 4553, Pr. Etienne Chatelut and Pr. Jean-Pierre Delord, Toulouse, France). CIFRE Grant
    • Determination of the role of Hospicells (ovarian stromal cells) alone or in association with ovarian cancer cells in the tumor angiogenesis in vitro.
    • Study of the role of Hospicells in the macrophage recruitment and differentiation.
    • Study of the cellular pathways implied in the activation of ovarian cancer cells and macrophages by Hospicells.
    • Analysis of the incorporation of an anti-cancer molecule derivated from the etoposide and linked to a spermin chain (F14512) in human ovarian samples (tumoral ascitic fluid and tumor fragments).

  • Institut Claudius Regaud - Master of Sciences 2nd year Trainee

    2008 - 2009 Study of the crosstalk between ovarian adenocarcinoma cells and their microenvironment mediated by the interleukins 6 and 8, under the direction of Pr. Bettina Couderc, Claudius Regaud Institute (EA 3035, Pr. Roland Bugat, Toulouse, France).
    • Determination of the interactions established in vitro between ovarian cancer cells and Hospicells (ovarian stromal cells).
    • Study of the cellular pathways implied in the activation of ovarian cancer cells by Hospicells.

  • IPBS - Master of Sciences 1st year Trainee

    2008 - 2008 Development of cellular tools allowing the purification of partners and subrates of the Hck protein, IPBS (Dr. Isabelle Maridonneau-Parini, Toulouse, France).
    • Development of cell lines allowing the inducible expression of Hck protein linked to a biotin tag.

Formations

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