University of Haute-Alsace
- PhD in Organic Chemistry
2011 - 2014
“Synthesis of mycolactone mimetics for the mechanistic study of Buruli ulcer”, supervisor: Dr. N. Blanchard
Organic synthesis: Multi-step synthesis, total synthesis, asymmetric synthesis, organometallic chemistry, fluorine chemistry, therapeutic chemistry.
Familiar with modern analytical techniques (NMR, (RP-)HPLC, HRMS).
Computing: Internet, windows environment, NMR softwares (MestRec, WinNMR, ACD/Labs…), molecular drawing softwares (ChemDraw, IsisDraw…), bibliographic research (SciFinder, Reaxys), molecular modeling softwares (Winmopac, ChemBio3D), chromatography (Chromeleon).
Teaching: First year of PhD (November 2011-April 2012), 64 h of hands-on training in organic chemistry, 32 h with first year of engineering school students and 32h with second year of engineering school students.
Second year of PhD (October 2012-April 2013) 76 h of hands-on training in organic chemistry, 24 h with first year bachelor’s degree students, 28 h with second year bachelor’s degree students and 24 h with third year bachelor’s degree students.
Research management: Supervisor of three internships, Mrs Emilie Clauzier (Mai-June 2012, second year of engineering school), Mrs Cécilia Zouggari (Mai-June 2013, second year of engineering school), and Mr. Aymeric Dolbois (February-July 2014, third year of engineering school).
Co-organizer of the 2013 annual meeting of the Organic Chemistry Department of the University of Haute-Alsace (Journée de la biologie et de la chimie), 6th edition, 20th June 2013. Invitation of the lecturers (Dr. B. Nay from the Muséum National d’Histoire Naturelle, Paris - France and Dr. C. Vonthron from the university of Strasbourg - France), selection of the students for the oral presentations and for the posters session
Organizer of the laboratory group meetings (November 2012 - December 2013).
Scientific production : “History, Biology and Chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)” Anne-Caroline Chany, Cédric Tresse, Virginie Casarotto, Nicolas Blanchard, Nat. Prod. Rep. 2013, 30, 1527.
"Total synthesis, an essential tool for the understanding of Buruli ulcer" Anne-Caroline Chany, Cédric Tresse, Virginie Casarotto, Nicolas Blanchard, Actual. Chim. 2014, 381, 28-33.
“Practical Methods for the Synthesis of Trifluoromethylated Alkynes: Oxidative Trifluoromethylation of Copper Acetylides and Alkynes” Tresse C., Guissart C., Schweizer S., Bouhoute Y., Chany A.-C., Goddard M.-L., Blanchard N., Evano G., Adv. Synth. Catal. 2014, 356, 2051-2060.
"Turning unreactive copper acetylides into remarkably powerful and mild alkyne transfer reagents by oxidative umpolung" Evano G., Jouvin K., Theunissen C., Guissart C., Laouiti A., Tresse C., Heimburger J., Bouhoute Y., Veillard R., Lecomte M., Nitelet A., Schweizer S., Blanchard N., Alayrac C., Gaumont A.-C. Chem. Commun. 2014, 50, 10008.
"Synthetic Variants of Mycolactone Bind and Activate Wiskott-Aldrich Syndrome Proteins" Chany A.-C., Veyron-Churlet R., Tresse C., Mayau V., Casarotto V., Le Chevalier F., Guenin-Macé L., Demangel C., Blanchard N., J. Med. Chem., 2014, 57, 7382.
“Shaping mycolactone for therapeutic use against inflammatory disorders” Guenin-Macé L., Chany A.-C., Tresse C., Jönsson F., Oldenburg R., Baron L., Mayau V., Le Chevalier F., Bruhns P., Bismuth G., Hidalgo-Lucas S., Bisson J.-F., Blanchard N., Demangel C., Sci. Transl. Med. 2015, 7, 289ra285.
“Stereodivergent Hydrogermylations of α-Trifluoromethylated Alkynes and their application in Cross-Coupling Reactions” Schweizer S., Tresse C., Bisseret P., Lalevée J., Evano G., Blanchard N., Org. Lett. 2015, 17, 1794.
“A walk across total synthesis of mycolactone analogs – mechanistic implications in Mycobacterium ulcerans infection” Blanchard N., Chany A.-C., Tresse C., Bréthous L., Saint-Auret S., in Strategies and Tactics in Organic Synthesis, Ed. Harmata, M.; Ed. Academic Press 2015; Volume 11, pp 85-117.
PhD defended on September, 29th, 2014.
