ROSCOFF
I have a PhD degree from the University of Rennes 1 in Roscoff, France in Biochemistry and Molecular Biology. I have subsequently worked in a pharmaceutical company Intervet Innovation GmbH (Germany).
I am skilled in article writing as well as writing grant applications. Also, during my Ph.D. project I have learned about Project Management, Monitoring and Reporting, Evaluation and Risk assessment, Scientific vulgarization, Setup of budgets, Defended scientific work at international meetings, Computer: MS Office, Adobe Acrobat, Internet tools as well as Scientific monitoring and business intelligence. Moreover,I'm a very outgoing and social person and enjoy travelling and meeting new people and cultures. Since I already have travelled quite a lot, I speak several languages including English, Danish, Spanish, French, and German. The countries where I have lived include: Bahrain, Spain, Denmark, Dubai (U.A.E.), England, France and Germany. Furthermore, I am very enthusiastic, disciplined, and a hard-worker
During the 7 month contract at Intervet Innovation GmbH, I have developed novel methods to grow parasites in vitro for the screening of candidate anthelmintics. Thus creating a link between candidate drug development and discovery and pre-clinical testing of larval species including Haemonchus contortus, Trichostrongylus colubriformis, Cooperia oncophora, and Oesophagostomum dentatum.
I was awarded a Marie Curie Fellowship in France, Roscoff, at the renowned marine station Station Biologique de Roscoff (www.sb-roscoff.fr) in the lab USR3151 "Protein Phosphorylation and human pathologies", under the supervision of Prof. Laurent Meijer.
His main focus is on protein kinases and on the cell cycle. He is very renowned in the field of protein cyclin-dependent kinases (CDKs). He found Roscovitine to be a potent CDK1 and -2 inhibitor (http://en.wikipedia.org/wiki/Seliciclib ). He has created a spin-off named ManRos Therapeutics.
The goal of my PhD thesis at his lab, was to screen marine-derived compounds on a panel of different cancer cell lines. I found a group of compounds named lamellarins to be toxic for cancer cell lines by inhibiting various protein kinases and by inhibiting topoisomerase II.
Lamellarin analogues were created to optimize the structure activity relationship. These have the potential to become possible drug candidates for certain forms of cancers.
My MSc was performed in KMEB under the supervision of Prof. Moustapha Kassem. The MSc project was in the culturing of human embryonic stem cells (hESCs), which traditionally are grown on mouse fibroblasts. This, of course, is a limitation if hESCs are to be used for transplantation purposes. I found that decellularized human fibroblasts were successfull at maintaining hESCs undifferentiated.
While carrying out my MSc in the University of Southern Denmark, I took the opportunity to follow a certificate course in animal handling and am therefore certified to work with animals. I have extensive experience in cell culture, qPCR, western blotting, flow cytometry, microscopy, etc.
Mes compétences :
Anglais
Cancérologie
Communication
Danois
International
Sciences de la vie
