LE PLESSIS ROBINSON
MBE de Bioinformatique (EBI Ecole de Biologie Industrielle Cergy)
DEA Biologie de l’os et des articulations (mention A.B.) (Université Denis Diderot Paris VII)
Compétences :
- Gestion de projets bioinformatiques
- Développement d'outils d'analyse
- Analyse statistique de puces à ADN
- Création, programmation et gestion de bases de données
- Création et gestion de sites web
-Langages (Language R, PHP/Mysql, HTML/javascript, PERL, C/C++, Java)
-Outils informatiques (R/Bioconductor, Ingenuity, Genespring, Excel (VBA), SAS)
-Méthodes statistiques (Analyse de puces à ADN, Normalisations, Bootstrap, ANOVA, Clustering Hiérarchique, KNN, LSimpute)
-Outils Internet (Bases de données publiques, FASTA/BLAST, NCBI, EBI, Ensembl, etc..)
-OS (Linux, Windows)
Développement logiciel:
eVenn (v2.1.4) (Package R, Octobre 2011)
GExMap (v1.1.3) (Package R, Octobre 2011)
AnnotLists (v1.2) (Package R, Octobre 2011)
Publications scientifiques:
- Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.
Cros J et al. (Immunity. 2010)
- The transcription factor SRF regulates hematopoietic stem cells adhesion.
Ragu C et al. (Blood. 2010)
- IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells.
Grinberg-Bleyer Y et al. (J Exp Med. 2010)
- Gene expression profile in the salivary glands of primary Sjögren's syndrome patients before and after treatment with rituximab.
Devauchelle-Pensec V et al. (Arthritis Rheum. 2010)
- GExMap: An Intuitive Visual Tool to Detect and Analyze Genomic Distribution in Microarray-generated Lists of Differentially Expressed Genes.
Cagnard N et al. (J Proteomics Bioinform 2009)
- Comprehensive Linkage and Association Analyses Identify Haplotype, Near to the TNFSF15 Gene, Significantly Associated with Spondyloarthritis.
Zinovieva E et al. (PLoS Genet. 2009 June)
- The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
Mercher T et al. (J Clin Invest. 2009 April 1)
- Gene expression profiling provides insights into the pathways involved in solid pseudopapillary neoplasm of the pancreas.
Cavard C et al. (J Pathol. 2009 Jan 20)
- GExMap: An Intuitive Visual Tool to Detect and Analyze Genomic Distribution in Microarray-generated Lists of Differentially Expressed Genes.
Cagnard N et al. (Proteomics Bioinform 2009)
- FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.
Fabre S et al. (J Immunol. 2008 Sep)
- CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.
Gottenberg JE et al. (Arthritis Res Ther. 2007)
- Failure to confirm coxsackievirus infection in primary Sjögren's syndrome.
Gottenberg JE et al. (Arthritis Rheum. 2006 Jun)
- Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome.
Gottenberg JE et al. (P.N.A.S. 2006 Feb 21)
- Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes.
Cagnard N et al. (Eur Cytokine Netw. 2005 Dec)
- DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets.
Devauchelle V et al. (Genes Immun. 2004 Dec)
Mes compétences :
Analyses statistiques
Bases de données
Bio-informatique
Bioinformatique
Développement
Gestion de projets
Programmation
Statistiques
Analyse statistique
Base de données
Gestion de projet
