Paris
- Present experience:
An effective immune response to protein antigen relies on the helper T cell regulated development of high-affinity B cell memory and its consolidation after the vaccine boost. The cognate T cell help involves specific interactions between T cell receptor and peptide–major
histocompatibility complex class II molecules (pMHCII), cytokines and co-stimulatory molecules that regulate commitment to antibody isotype switch, plasma cell development and the germinal center pathway.
After initial priming with an antigen-experienced Dendritic cells, antigen-specific TH cells are clonally selected and expand drastically. These events result in the development of antigen-specific effector TH cells. Among them, Follicular Helper T (TFH) cells are considered as
the critical regulators of the B cell response. Until recently, TFH cells were considered fully differentiated cells prone to apoptosis. However, we obtained compelling evidence that effector TFH cells become memory TFH cells that remain in draining lymphoid tissue.
Our project is divided in 3 specific aims:
1) TFH cell differentiation and Plasticity of Effector TH cell subsets.
2) Physiological role of Memory TFH cell Retention and manipulating TFH cell responses in vivo.
3) TFH cells in pathological conditions.
- Past research experience:
+ McHeyzer-Williams Lab, The Scripps Research Institute, San Diego, CA, USA.
Basic Research on memory T cells which regulate antigen-specific B cell responses in vivo.
+ Pasteur Institute, Paris, France, Unit INSERM U277 directed by P. Kourilsky, PhD studies under the supervision of J. Kanellopoulos.
Basic Research on diversity of antigen receptors of T lymphocytes
+ Karolinska Institute, Stockholm, Sweden, Training course under the supervision of E. Linder.
Basic Research on schistiosomasis
Mes compétences :
Biotechnology
Design
Immunology
Research
Scientific
Scientific research
Pas de formation renseignée
