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Paul-Emile POLENI

Dax

En résumé

Not needed

Mes compétences :
Biochemistry
Biology
Cell Biology
ChIP
Engineering
Expérimentation
Médical
Molecular biology
Pharmacology
Physiology

Entreprises

  • Okinawa Institute of Science and Technology - Staff Scientist

    Dax 2015 - maintenant

  • Miyazaki University, Graduate school of Medicine - Researcher

    2012 - 2015 Development of an innovative cell-based cDNA library screening for the discovery a AMPAR's ectodomain-interacting proteins.

    Keywords: Screening - Genetics - Trans-cellular protein-protein interaction-synaptic plasticity.

    Teaching experience / mentorship

  • University of Miyazaki, Graduate School of Medicine - Researcher

    2010 - 2012 Evidencing the role "Vagus Nerve-Brainstem-Hypothalamus" ascending neuronal pathway in the regulation of feeding in vivo.

    Molecular mechanisms of energy homeostasis in the Central Nervous System in vivo and in vitro.

    Keywords: Neuroendocrinology-Obesity-Energy Homeostasis-Neurosurgery-Molecular Biology-Animal Experimentation.

    Teaching experience.

    Reviewing articles: J Endocrinology & J Mol Endocrinol.

  • University of Technology (UTC) Compiègne - Postdoctoral Fellow

    2009 - 2010 1) Development of a dynamic "Liver-Kidney" co-culture biochip dedicated to drugs (PB/PK) studies.

    Keywords: BioMEMS - Co-culture- Closed loop Circuit-Metabolism of Ifosfamide-ADME.

    2) Implementation/set up of a platform for the isolation/culture of primary rat hepatocytes.

    Keywords: Animal Experimentation - Double Liver Perfusion - Cell Culture.

  • LIMMS / University of Tokyo - Postdoctoral Fellow

    2006 - 2009 Micro-technologies (BioMEMS-advanced MEMS - Nanotechs) for biology and medicine.

    Projects/collaborations:

    1) Effect of the geometry on hepatic cell behavior (with Serge OSTROVIDOV).
    Proc. ESAO (J. Artif. Organs) 2009.

    2) Generation of 20um mono disperse alginate beads (with Serge OSTROVIDOV).
    Eposter.net

    3) Effect of the intrinsic physical features on hepatic cells topography and activities (with Nazare PEREIRA RODRIGUES and Denis GUIMARD).
    PloS ONE, J Nano Res etc…

    4) O2/Glucose Sensors for the on-line monitoring of cellular activities in a microchip (with Nazare PEREIRA RODRIGUES, Olivier DUCLOUX and Hiroshi KIMURA).
    Proc. MMB 2009.

    5) 3D dielectrophoresis (face to face electrodes) for the patterning of cells in 3D. (with Erwan Lenon)
    Not fully completed.

    6) Microwave spectroscopy for cell biology and drugs testing (Katia GRENIER and David DUBUC).
    RWS2010, IMS2009, TMTT.

    7) Pressure driven cells focused on a microchip (with Olivier DUCLOUX and Serge OSTROVIDOV).
    Proc. MicroTAS, ePoster.net, Lab Chip Euro Congres.

  • UHP-NANCY 1, Graduate School of Medicine - PhD researcher

    2003 - 2006 PPAR agonists inhibit TGF beta-induced chondrocytes responses.
    Collaborator: Stephanie ETIENNE.

    Anti-inflammatory/arthritic potency of PPAR agonists in vivo and in vitro.
    Meriem KOUFANY's project.
    David MOULIN's project.

    Keywords: Pharmacology-TGF beta- PPAR activators-Extracellular Matrix Turnover-Animal Experimentation-3D culture in alginate beads.

    Technical management (undergraduate and graduate students as well as technicians).

    Tutoring: Julien DARMIAN (Ecole Polytechnique); research theme: link between leptin and osteoarthritis in OA patients ? Natalie Presles' project.

    Other projects/collaborations:
    1)Benefits of Glucosamine-HCl in cartilage repair (before the project Glucosamine plus chondroitins or Structum).

    2)Metabolic syndrome and cartilage (Glucose metab/IGFR/GAGs neosynthesis) (Valerie OLIVE, Master II).

    3) HSP70 / chondroprotection in vivo and in vitro (Stephanie ETIENNE, EPHE).

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