AIX EN PROVENCE
I obtained my PhD in Neuroscience from the Université de la Méditerranée Aix-Marseille (France), where I worked mainly on the neuropathogenesis of Congenital Cytomegalovirus infection through a model of in utero infection of the rat brain. During my PhD, I demonstrated by immunohistochemistry and flow cytometry that embryonic infection triggered dysexpression of chemokines, attraction of peripheral immune cells and early microglial activation. Moreover, I showed that specifically targeting microglial cells during pregnancy by decreasing their activation state, was associated with increased survival and a prevention against tonico-clonic seizures and sensorimotor disturbances. At Neurochlore, I have co-developed with Dr Riffault, a whole-mount immunostaining clearing method allowing three-dimensional study of nervous system in order to decipher developmental changes and pathological issues in different animal models of neurological disorders.
