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Séverine DUBOIS

MARLY-LE-ROI

En résumé

As junior clinical project manager, I recently followed training for « Clinical Project Manager » and i acquired management skills by setting up a clinical trial in obese and lean subjects during my post-doctoral position in USA. During my last job, my role as senior researcher was to analyze and look for toxicity and clinical results of repositioned drugs. I acquired also expertise in pre-clinical development (in vitro and in vivo) as R&D project manager in a pharmaceutical company in Australia. I also developed, from my 15 years professional experience in public (French and American) and private research (French and Australian), a significant expertise in in vitro and in vivo analyses. I am also an occasional reviewer for the editorial office of science domain international for reviews such as British Journal of Medicine and Medical Research.

Mes compétences :
Obesity
Diabetes
human nutrition
Magnetic Resonance Imaging
Liposuction
Cell Culture
vitro model experiment development
segregation analysis
molecular genetics
epidemiological analysis
SPSS
SAS Statistical Package
Preclinical Development
Parental transmission analysis
Method development
Clinical Trials
Biopsy

Entreprises

  • Industrie Pharmaceutique - Senior Researcher

    2012 - 2016 *Biologic Systems Researcher: Molecular network construction in silico for several diseases
    (Diabetes, Myopathies, Schizophrenia).

    * Off patent drugs repositioned on disease networks, analyzed for toxicity and clinical results and send to experimental biology department.

  • Inserm - Senior Researcher

    PARIS 13 2009 - 2012 *Type 2 Diabetes new gene targets analysis: in vitro molecular experiments and cell culture of primary adipocytes (GK rats) and stable cell lines (3T3-L1)

    *In vivo GK rats maintenance *Writing referral for animal experimentation to National Ethics Committee

  • Inserm - Senior Researcher

    PARIS 13 2008 - 2009 *Project in collaboration with chemists: Monitoring in vivo β cells and T Lymphocytes during pancreatic transplant.

    *Studies in vitro and in vivo of human and mice pancreatic islets labelled with magnetic particles.

    *Test on function and viability of pancreatic islets in vitro followed by MRI and IF studies.

    * In-vivo test of labelled Lt and pancreatic islets transplanted in irradiated NOD mice (sinusoidal injection and renal capsule transplant).

    *MRI of pancreatic islets transplanted NOD mice

    *In-vitro culture of human isolated pancreatic islets and HUVECS to analyse angiogenesis gene pathway following high glucose treatment: QPCR, proteome analysis, angiogenesis assay

    *International articles and reports writing

  • ChemGenex - Pre-clinical Project Manager

    2005 - 2007 Pharmaceuticals/Metabolic Research Unit-Deakin University-Waurn Ponds, VIC-Australia

    * In vitro and in vivo drugs screening for Type 2 Diabetes

    * In vitro model experiment development of insulin resistance induced by palmitate and TNFα in adipocytes
    *In vivo drugs screening in diabetic Psamommys obesus (P.Obesus) rats
    *Reports and patents writing
    *Collaborative project with Merck-France-Principal investigator-Study of a new drug compound in in-vivo animal models for type 2 diabetes (P .Obesus)
    *Honours student supervisor: Role of Metallothionein in insulin resistance

  • Pennington Biomedical Research Center - Post-doctoral Research Fellow

    2002 - 2004 Post-doctoral Research Fellow-Human Physiology Unit-Pennington Biomedical Research Center-

    *In vitro work on fat cell metabolism in human isolated adipocytes of type 2 diabetic and nondiabetic patients: QPCR, Western Blot analyses

    *Method development for primary cell culture from needle adipose tissue biopsy versus
    liposuction samples in human subjects-collaborative project

    *Setting up a clinical trial in obese diabetic and control patients

    *International articles writing

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