Abdelkader HAMADI

En résumé

Entreprises

• Quintiles - Clinical Data Programmer

  Durham 2014 - 2015 : Clinical Data Programmer, Quintiles. Data and Safety Monitoring department Strasbourg, Lead Programmer managing all aspects of databases design and clinical data deliverables for studies in a broad therapeutic areas as oncology and rheumatoid arthritis and clinical phases III-IV.
  * Lead or contribute to the design, creation and lifecycle management of data collection, validation, analysis and/or reporting systems/software programs (e.g. Oracle Clinical, SAS).
  * Develop and maintain edit check specifications/derivation and validation programming/ Protocol deviation.
  * Identify the SDTM observation class and domains and develop aCRF for data collection according to CDASH standards.
  * Develop specifications for multiple data transfers and program Data Transfers with clinical data standards (CDISC-CDASH/SDTM).
  * Ensure mapping and traceability between eCRF and SDTM. ;
  * Program of complex listing and report as SAE reconciliation, missing eCRF pages, predicted visits...
  * Specify and program a non-CRF data import and integration (IVRS, LABS...).
  * Assist in the review of key study-related documents produced by other functions, including study protocols, case report form, database specifications, EDC data structures, data transfer plans to provide input from Programming perspectives.
  * Interact and communicate with Data Managers, Statisticians to address programming related study deliverables as needed.
  * Proactively address operational issues related to clinical systems. ;

• Laboratory of Epidemiology and Public Health - Clinical and Epidemiological Data Manager

  2010 - 2014 : Clinical Data Manager. Laboratory of Epidemiology and Public Health, and Bas-Rhin Cancer Registry (first general cancer registry in France). University of Strasbourg School of Medicine,
  * Managed data of observational prospective and multicenter clinical study on pediatric orofacial malformations
  * Estimated the prevalence of autoimmune diseases in the region of Alsace with capture-recapture technique
  * Participated in a study of methodology for risk assessment in vaccine pharmacoepidemiology
  * Completed regulatory documents, elaborated and tracked budget, managed contracts
  * Designed annotated case report forms (CRFs), databases and entry forms, developed study questionnaires & surveys
  * Specified and programmed coherence controls (type, range and relational tests) to ensure data quality
  * Processed and homogenization of large data from 9 cancer registries for research purpose
  * Generate listings by cross-check data of registry and hospital/death databases
  * Create program to perform automatic calculation of questionnaires scores
  * Performed data processing and statistical analysis and reported and communicated results to investigators/sponsors ;

• CNRS - Postdoctoral Scientist

  Paris 2009 - 2009 : Postdoctoral Scientist: CNRS, Institute of Cell Biochemistry and Genetics.
  * Analyzed early markers of cell quiescence/proliferation transition (Oncology/ aging). ;

• CNRS - Postdoctoral Scientist

  Paris 2009 - 2009 : Postdoctoral Scientist: CNRS, Institute of Cell Biochemistry and Genetics.
  * Analyzed early markers of cell quiescence/proliferation transition (Oncology/ aging). ;

• CNRS/Institut de biochimie et de biologie cellulaire - Chercheur contractuel/la machinerie de la quiescence cellulaire

  2009 - 2009 Projet: Etude de l’état d’assemblage et de l’activité du protéasome 26S et le remaniement de l’architecture nucléaire lors de la transition prolifération/quiescence cellulaire chez Saccharomyces cerevisiae.
  
  Compétences transverses
  -gestion de banque de cellules >5000 souches, de plasmides et d’oligonucléotide.

• Université de Strasbourg/Faculté de pharmacie - Moniteur/ATER

  2004 - 2008 -Encadrement d’étudiant en master 2 recherche dans la conduite de leur projet de recherche.
  -Encadrement de travaux pratiques de pharmacologie/physiologie pour les étudiants de pharmacie et de master pharmacologie (Faculté de pharmacie, Strasbourg).
  -Formation pour le public de l’entreprise sur les concepts de base en imagerie digitale et la microscopie confocale. Département d’éducation permanente de l’Université de Strasbourg.
  Ces missions englobent: Hygiène et sécurité, bonnes pratique de laboratoire, évaluation....

• Université de Strasbourg/Faculté de pharmacie - Chercheur allocataire/oncologie/migration cellulaire/interaction cellules-matrice extracellulaire

  2003 - 2008 Etude de l’implication de FAK (kinase des points d’adhérence) dans l’invasion tumorale : analyse de la dynamique et du désassemblage des points d’adhérence cellulaires des astrocytomes/fibroblastes FAK-/- exprimant différents mutants FAK conférant soit un gain ou une perte de phosphorylation.
  
  Expertises scientifique :
  -Biologie cellulaire et moléculaire
  -Analyse de la progression tumorale et la migration cellulaire/ adhérence cellule-matrice extracellulaire
  -Etudes des marqueurs de la quiescence cellulaire : remaniement du protéasome et l’architecture nucléaire
  -Signalisation cellulaire et biochimie
  -Imagerie cellulaire quantitative
  -Gestion de projet : définition/rédaction/faisabilité, gestion temps/ réalisation du projet, demande de financement
  -Veille scientifique et technologique
  -Communication écrite et orale en anglais et en français
  -Langues : bilingue Français/Arabe, Anglais courant
  
  Expertises techniques :
  Culture cellulaire : adhérente/non-adhérente// clonage moléculaire et PCR// expression des protéines recombinantes// western blot// immuno-précipitation// immuno-cytochimie// Cytométrie en flux (tri cellulaire)// imagerie cellulaire ; microscopie à fluorescence/confocale et F-techniques : FRAP (Fluorescence Recovery After Photobleaching), FLIP (Fluorescence Loss In Photobeaching), FLIM (Fluorescence Life Time Imaging) et BiFC (Bimolecular Fluorescence Complementation)// traitements d’images (image j, etc..).

Formations

• University Of Strasbourg

  Strasbourg 2011 - 2012 Master of Science Evaluation, Clinical and Epidemiology Research

• University Of Strasbourg

  Strasbourg 2011 - 2012 Master of Science Evaluation, Clinical and Epidemiology Research

• University Of Strasbourg

  Strasbourg 2010 - 2011 Certification of investigator of clinical trials (DIU FIEC).

• University Of Strasbourg

  Strasbourg 2010 - 2011 Certification of investigator of clinical trials (DIU FIEC).

• University Of Strasbourg PhD Fellowship

  Strasbourg 2004 - 2008 Doctor of Philosophy
  
  * Demonstrated that a specific and controlled phosphorylation status of the protein FAK regulates tumor cell migration (Publication: Hamadi et al, J Cell Sci.2005; Hamadi et al, Cell Mol Life Sci.2009). ;
  * Supervised 4 M.Sc. students with no prior lab experience how became independent within 3-5 weeks
  * Gave 290 hours of pharmacology training to pharmacy students ;

• University Of Strasbourg

  Strasbourg 2004 - 2008 Doctor of Philosophy, Cell Biology

• University Of Strasbourg PhD Fellowship

  Strasbourg 2004 - 2008 Doctor of Philosophy
  
  * Demonstrated that a specific and controlled phosphorylation status of the protein FAK regulates tumor cell migration (Publication: Hamadi et al, J Cell Sci.2005; Hamadi et al, Cell Mol Life Sci.2009). ;
  * Supervised 4 M.Sc. students with no prior lab experience how became independent within 3-5 weeks
  * Gave 290 hours of pharmacology training to pharmacy students ;

• University Of Strasbourg

  Strasbourg 2004 - 2008 Doctor of Philosophy, Cell Biology

• Université Strasbourg 1 Louis Pasteur

  Strasbourg 2004 - 2008 migration cellulaire/adhérences cellulaires

• University Of Strasbourg

  Strasbourg 2003 - 2004 Master of Science, Pharmacology

• University Of Strasbourg

  Strasbourg 2003 - 2004 Master of Science, Pharmacology

• Université Strasbourg 1 Louis Pasteur

  Strasbourg 2003 - 2004 pharmacologie cellulaire et moléculaire

Réseau

• Christophe MARMIÉ

• Claude SCHELL

• Emmanuelle FREY

• Friteau LAURENCE

• Halima-Assia KERDJOUDJ

• Ilana THOMANN

• Inès MRABET

• Kneib MARIE

• Nathalie LUSSIER

• Samir BENOSMAN