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IRC - Regional Cancer Institute - Paul Strauss Center - University Hospital of Strasbourg
- Bioinformatician
2013 - maintenant
Exome sequencing analysis dedicated to cancer diagnostic and prognostic, and rare and complex disease understanding. The aim is to develop a daily clinical routine pipeline, in collaboration with molecular biology and haematology labs at HautePierre hospital and with the oncology lab at Paul Strauss center.
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Swiss Institute of Bioinformatics - University of Lausanne
- Bioinformatician at Vital-IT and the Medical Genetics Department of the UNIL
2012 - 2013
Exome sequencing analysis (causative variant), at Vital-IT group (Swiss Institute of Bioinformatics), in collaboration with the Statistical Genetics Group at the Department of Medical Genetics and the CHUV.
Development and implementation into the daily clinical routine of a comprehensive pipeline (from the sequencing to the data interpretation) dedicated to exome sequencing analyses, which aim is to identify rare genetic variants associated to rare diseases and more complex pathologies. This project relies on strong collaborations with Vital-IT/Swiss-Prot groups (SIB), the Lausanne University Hospital (CHUV) and the Department of Medical Genetics (DMG).
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Université du Luxembourg
- Assistant Chercheur
2010 - 2012
Analysis of gene regulatory networks to identify biologically relevant sub-networks explaining transitions between cellular phenotypes. Development of a discrete logic modelling optimization approach guided by network dynamics [XPred project – maia.uni.lu/XPred] (LCSB collaboration, Luxembourg). Application in cancer processes such as metastasis, anoïkis resistance (ISB collaboration, Seattle), epithelial/mesenchymal transition (EMT/MET) as a dynamic system.
(Systems Biology, Gene Regulatory Networks, Network modeling, topology and dynamics, Transcriptomics, Cancers)
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Université du Luxembourg
- Post Doctorant Chercheur
2008 - 2010
Construction and analysis of meta-regulation networks integrating transcription factors, microRNAs and targeted coding genes, in order to detect relevant network motifs, such as feedback and feed-forward loops [MIR@NT@N project – mironton.uni.lu]. Application in epithelial to mesenchymal transition (EMT) processes in breast cancer.
(Integrative Biology, Meta-regulation Networks, Transcriptomic & Post-transcriptomic regulations, Cancer and EMT)
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CNRS 6026
- Post-Doctorant Chercheur et Enseignant
2007 - 2008
Analysis and integration of proteomic data related to amyloïd proteins, mainly involved in the most serious neurodegeneratives diseases such as Alzheimer, Huntington and Parkinson [AMYPdb Project – amypdb.univ-rennes1.fr]. Classification method using a multi-pattern-matching approach, applied to major intrinsic proteins [MIPdb project – mipdb.genouest.org].
(Sequence annotation, Protein pattern & motifs, Database conception, Knowledge repository, Amyloidosis)
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Université de Rennes 1 / INSERM U620 / CNRS 6026
- ATER - Enseignant Chercheur
2006 - 2008
Enseignant Chercheur en Bioinformatique
Enseignement en Licence et Master dans les disciplines Informatique et Bioinformatique
Recherche en Biology Intégrative, analyse des données transcriptomiques et exploitation des réseaux de gènes
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CEMAGREF / INSERM
- Consultant
2005 - 2006
Conseils en Gestion de Connaissance et Système d’Information
Knowledge Management Systems (KMS) development to manage data and processes with a multiuser web-based environment [RM@LIMS project].
Content Management System (CMS) implementation to improve research laboratory communications, data storage and efficiency [ARI@NE Project].
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INSERM U620
- Doctorant
2003 - 2007
Étude du cancer du foie par analyse bioinformatique de données d’expression de puces à ADN :
- Développement d’un environnement d’analyse et d’interprétation de données d’expression génétique (Projet M@IA, Datamining, Biologie Intégrative, Méta analyse de données, Réseaux Métaboliques...)
- Élaboration d’un environnement informatique de gestion de connaissances (Projet ARI@NE, Réseau Intranet d’un Laboratoire de Recherche)
Management, analysis and integration of transcriptomic data in hepatocellular carcinoma. Environment dedicated to gene expression data annotation and analysis, integration of biological knowledge and interaction graph analysis [M@IA Project – maia.genouest.org].
(Integrative Biology, Interaction Graphs analysis, Transcriptomic analysis, Meta-analysis, Gene regulatory networks)
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Université de Rennes 1
- Moniteur - Enseignant Chercheur
2003 - 2006
Enseignements en Licence et Master dans les disciplines Informatique et Bioinformatique
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INSERM U620
- Analyste développeur
2003 - 2003
Élaboration d’un cahier de laboratoire électronique pour la gestion des expériences menées sur le transcriptome et le stockage des données d’expression de gènes (Projet M@LIMS)
Development of a laboratory information management system (LIMS) dedicated to transcriptomic experiments (microarray), and gene expression data storage and annotation [M@LIMS Project].
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CRDP de Bretagne
- Analyste Développeur
2002 - 2002
Analyse et développement d’une application pédagogique diffusant des documents multimédia et vidéo par l’Internet (Projet Gens de Bretagne)
Development of a web environment diffusing multimedia contents for French high school ("Gens de Bretagne" Project).
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INSERM U620
- Analyste Développeur
2002 - 2002
Entrepôt de Données en BioInformatique
Modélisation et mise en place d’une base de données pour la gestion des expériences de puces à ADN en collaboration avec l’INSERM U533 et la Génopôle Ouest (Projet M@DSTAR V2)
Development of a microarray database in collaboration with Nantes Hospital and Ouest Genopole [MADSTAR Project].
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S.D.I.
- Analyste Programmeur
2001 - 2001
Analyse et programmation d’applications Progiciel de gestion pour l’entreprise.
Development of enterprise management systems (accounting, salary, strategy).
