Bertrand CHOL

En résumé

Entreprises

• Pierre Fabre - Biotechnological Process Development and Production Manager

  Castres 2006 - maintenant Since 2006 Biotechnological Process Development and Production Manager. Pierre Fabre Laboratories St Julien en Genevois. Microbiological process optimization and development from laboratory-scale to industrial-scale. Clinical batches production (phase I to III) for cosmetic and pharmaceutical use. Pilot and manufacturing plant supervision in GMP environment. Team management (10 persons).

• Merck Santé - Screening Research Engineer

  Darmstadt 2003 - 2003 Screening Research Engineer. Research Center Merck Santé, Lyon (6 months assignment). Elaboration and automation of cellular and molecular screening test for anti-diabetic compounds. Eukaryotic cell culture in multi-wells plate and tranfection conditions optimization. Technical procedures and scientific reports writing. Responsible for two technicians

• PX-Therapeutics - Bioprocess Development Engineer

  Grenoble 2003 - 2006 2003-2006 Bioprocess Development Engineer PX-Therapeutics, (CMO) Grenoble. Protocol development for recombinant protein expression in E. coli and yeast. Optimization and scale-up of fermentation, extraction and purification process steps. Production of clinical batches (phase I). Set-up of analytical techniques. Negotiation with sub-contractors. Building scientific partnerships

• Diaclone Pharma - Head of clinical manufacturing.

  2002 - 2002 Head of clinical manufacturing. Diaclone Pharma (CMO), Besançon (4 months assignment). Hybridome culture in perfused bioreactors and monoclonal antibodies purification by chromatography. Clinical batches production (phase I and II). Implementation of GMPs in clean room

• Sanofi Pasteur - Head of vaccine manufacturing process validation.

  Lyon 2002 - 2002 Head of vaccine manufacturing process validation. Sanofi Pasteur, Lyon (6 months assignment). Retrospective process validation of microbiological vaccines manufacturing. Launch critical analysis, robustness and consistencies studies regarding industrial fermentation and downstream production steps. Validation protocol and report writing. Supervising two technicians

Formations

• Université Clermont 2 Blaise Pascal CUST

  Aubiere 1997 - 2000 Biotechnology

Réseau

• Am DEVANT

• Antoine THERY

• Aurélie VIVARES

• Benoit CLARET

• Christophe GROUX

• David CHAUVINEAU

• Hélène BLONDEL

• Hélène CHAUTARD

• Pierre VERCHERE

• Sonia ARDEBILI