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Frederic LEROY

LYON

En résumé

PROFILE

> 15 years of expertise in organic chemistry

Manager:
– Teams of chemists (1-10 technicians/PhD)
– Projects management (scientifically, technically, QC, quotes, planning, costs)
– Budget and resources management
– National and international client portfolios management

Expertise :
* Organic chemistry / chemical processing development / ultra- and nano-filtration
* Nucleic Acid, Heterocycles, Carbohydrates, Poly- and Oligosaccharides, Macrocycles, Fluorine
and Phosphorus Chemistry.
* Medicinal Chemistry – Flaviviridae viruses, Hepatitis C (protease NS3/NS4A, polymerase NS5B),
Diabetes (Ultra-fast Acting, Fast and Long Acting Combo, Diabetic Foot Ulcer),
Oncology (targeted Nano-delivery).

Identification of new potential markets (carbohydrates, oligosaccharides and nucleic acids)

Responsible for and worked in a research collaboration with CRO and academic partners

Entreprises

  • Elicityl - Crolles (Fr) - Head of OligoTech and custom products and Chemical Advisor: oligo- et polysaccharides

    2017 - maintenant

  • Novasep - Chasse Sur Rhône (Fr) - Project Manager

    POMPEY 2016 - 2017 Mission: Lead R&D projects in organic chemisty from elaboration of the technical proposal to the customer to the operational management.

  • Graines de SOL – Pierre-Bénite (Fr) - Independent Chemistry Consultant

    2015 - 2017 Mission: Bring my scientific expertise and knowledge in the field of organic and medicinal chemistry

    * Analysed scientific and technical problems in nucleic acid chemistry’s field.
    * Identified new potential market for in the field of oligosaccharides.
    * Identified new chemical routes for 2 CMC medicinal chemistry projects.
    * Bring my general expertise for a collaborative deal with an international pharma in oncology.
    * Indentified and led two R&D programs for collaborative academic/private partnership
    (phosphoramidites and oligosaccharides).

  • Adocia - Lyon (Fr) - Head of Chemistry Department

    2014 - 2015 Mission: Lead research, development and production of new pharmaceutical excipients
    to be used in formulation of therapeutic proteins or drugs for treatment of chronic
    diseases or cancer

    * Management of a team of 8-12 technicians/PhD chemists and the Adocia R&D laboratory.
    * Organic chemistry expertise: excipient, polysaccharides, peptides and polymers.
    * R&D on BioChaperone products for treatment of diabetes.
    * DriveIn Technology (nanoparticles) for chemotherapeutic agents targeting tumor cells.
    * Responsible for and worked in a research collaboration with custom synthesis services companies.

  • Carbosynth Ltd - Milton (UK) - R&D Manager: Nucleic Acid Chemistry & Carbohydrates

    2012 - 2014 Mission: Develop the Carbosynth strength in nucleosides, both technically and commercially,
    and lead a group of chemists in developing products for customers and expanding the
    catalogue range

    * Head of the UK Carbosynth custom synthesis R&D laboratory:
    - Organic chemistry expertise: mainly carbohydrates and nucleosides (mono and oligomers)
    - Supervise a team of 7 chemists (projects/ human resources/quotes/collaboration/H&S..)
    * Establish the Carbosynth’s R&D laboratory in Milton Park: production and analytic equipments
    and risk assessment
    * Identify, develop and manage new potential markets:
    Over 25 deals sourced in, negotiated and signed in 2012
    * Create new products for the Carbosynth’s catalogue
    * Manage national and international client portfolios (biotech/Pharma/Universities
    * Develop and facilitate scientific presentations internationally (Europe and US)

  • independant - Consultant

    2011 - 2012 Mission: Bring my scientific expertise and knowledge in the field of organic chemistry

    * Identified new chemical routes for 8 CMC projects in medicinal chemistry.
    * Created and put in place a R&D collaboration with a French academic partner


  • Oxeltis - Montpellier (Fr) - Business Development Director and Scientific Program Manager

    2010 - 2011 - Originator and Co-founder of the Company: medicinal chemistry and custom synthesis services / nucleosides/tides, macrocyles, heterocyles, Phosphorus and Fluorine.
    - Identified, developed and managed new potential markets in the area of modified nucleosides
    - Managed client portfolios
    - Developed and facilitated scientific presentations internationally

  • Idenix Pharmaceuticals - Montpellier (Fr) - Senior Research Scientist

    2005 - 2010 - Hepatitis C: protease NS3/NS4A (macrocyles), polymerase NS5B (nucleosides and heterocycles): 8 patents / 5 articles / 2 oral presentations / 4 posters.
    - Team Leader
    - Responsible for and worked in a research collaboration with the academic research

  • Idenix Pharmaceuticals - Montpellier (Fr) - Research Scientist

    2002 - 2005 - Nucleosides and heterocycles for treating Flaviviridae: 3 patents / 2 articles / 4 posters.
    - Team Leader

  • Pharmasynthese (a.k.a Panchim) - Evry (Fr) - Chemist Engineer

    2000 - 2001 - Fine chemistry, custom synthesis / chemical processing development / Research & Pilot laboratory

  • Institut Chimie Organique Analytique - Orléans (Fr) - Post-doctoral position

    2000 - 2000 - Research project for SERVIER Company: alkaloids for their anti-tumoral activity / Multi-steps syntheses

  • Organic Synthesis Laboratory – University of Cergy-Pontoise (Fr) - PhD organic chemistry

    1994 - 1998 - Academic & Private Research project for HOESCHT/CLARIANT companies / precursors of carbanucleosides
    - Teachership of organic and general chemistry at University

Formations

Pas de formation renseignée

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