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Frederic VELLIEUX

VESTEC

En résumé

Researcher in macromolecular crystallography. Research interests include the study of the 3D structure of enzymes from the giant proteases of the TET family; proteases from the tropical parasites of the Trypanosoma genus, and other enzymes from parasites (trypanosomes, entamoeba histolytica). I am especially interested in the biomed applications of the 3D structures of proteins e.g. for the development of anti-cancer drugs. Other research interests include methodological developments in the field of macromolecular crystallography (in particular, at the moment, novel phasing methods).

Specialties: chemistry, crystallography, macromolecular crystallography, humanity

In my current position, my in-depth knowledge of crystallography, protein structure and function, and my experience in supervising and training are being put to use as the support man for the Core Facility aka Technical Platform.

Entreprises

  • First faculty of Medicine, Charles University - Senior researcher

    2018 - maintenant Senior researcher in Structural Biology. The development of novel medicine requires assessment using bioinformatics and 3D structure determination and analysis. This is what I do.
  • CMS, IBT of CAS, Biocev - Support man of the Centre of Molecular Structure (Scientific man.)

    2016 - 2018 Support man (Scientific man.), Centre of Molecular Structure
    Organising, expanding the CMS with new technologies.
    Providing support to the 3 (now 4) Scientists in Charge and to the Research Technician
    Organising an Instruct CIISB course (with workshop) on "Fragment Screening"
    Advertising the CMS to potential users
  • Commissariat à l'Energie Atomique - Postdoc CEA

    1991 - 2015 Développement de nouvelles méthodes en cristallographie des macromolécules biologiques
    Résolution et analyse de structures 3-D de protéines
    Ferredoxin:NADP+ Reductase
    Pyruvate Phosphate Dikinase de Trypanosoma brucei
    Malate Dehydrogenase de Haloarcula marismortui
    Malate Dehydrogenase de Archaeoglobus fulgidus
    Sulfolactate Dehydrogenase de Methanocaldococcus Jannaschii
    TET-1 de Pyrococcus horikoshii
    Malate Dehydrogenase de Chamsocephalus gunnari
    Malate Dehydrogenase de Deinococcus radiodurans
    Malate Dehydrogenase de Thermus thermophilus
    TET-3 de Pyrococcus horikoshii
    encadrement de stagiaires M1, M2
    encadrement d'étudiants en thêse et en post-doc
    conférencier invité et enseignant
  • Bioson Research Institute, Rijksuniversiteit Groningen - Post-doc

    1988 - 1991

Formations

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