Genticel
- Group Leader Bioprocess & Manufacturing
2009 - maintenantDevelopment of therapeutic vaccines against cervical cancer for women infected by Human Papillomavirus (HPV).
Work from pre-clinical to Phase III clinical stage
• Definition of CMC strategic and operational objectives
• Management of Process team
• Select and Pilot CMOs/CROs
• Manage Process Development, Transfer and Scale-up (Pre-clinical to Phase III clinical stages
• Manage Manufacturing and Release of Clinical batches (for Phase I and Phase II)
• Manage WCB and MCB Manufacturing
• Participate to preparation of regulatory files related to CMC for UE and US
• Screening of new therapeutic vaccine candidates
• Ensure the proper quality compliance level in accordance with Company standards
• Represent Bioprocess team in multidisciplinary project teams
Genticel
- Bioprocess Scientist
2007 - 2008• Development and optimization of Upstream, Downstream and Formulation processes for recombinant proteins
• Screening of new therapeutic vaccine candidates
• Optimisation of Expression System
UCB Celltech
- Fermentation Scientist
COLOMBES2005 - 2007Process Optimisation to increase Fab’ production rate in the periplasm
• Optimisation of Fab’ extraction process
• Conduct robustness studies on fermentation process to get supportive data in the context of AMM and BLA submissions
• Training of four persons to batch and fed batch fermentation processes
