Mes compétences :
dissolution
Emulsions
Formulation
Milling
Rhéology
Screening
Entreprises
Pfizer, UK
- Formulation Scientist
2006 - maintenantPFIZER R&D, Research Formulation
Until August 2009: Senior Associate Scientist
Since August 2009: Scientist
- Lead pharmaceutical science support for Pfizer Pain Therapeutic Discipline from Discovery / pre-clinical stages to First-in-Human (PhaseI) formulation:
* Strong hand-on formulation experience (Oral/Parenteral Drug Delivery) in discovery project and studies design, involving pharmaceutical science, material/physichem knowledge, PKPD and simulation techniques to help selection of new clinical candidates
* Strong interaction with Material Sciences for early solid form characterization and selection
* Influence product concept of new compound entities to deliver targeted therapeutic and safety margins using fit-for-purpose formulation strategies and/or enabling device
* Formulation development for regulatory toxicokinetic & GLP safety pharmacology studies
* Development and utilisation of novel technologies to improve the solubility/dissolution rate absorption, and bioavailability of poorly soluble drugs (Spray-Dried Dispersions, Nanotechnologies, SEDDS/SMEDDS formulations, amorphous technologies)
* Writing of regulatory documents in support of Phase I studies and strong interaction with Pfizer Clinical Units
- Additional skills: Lab safety coordinator, e-LNB deployment and implementation lead, group meeting organiser and chair
Colgate-Palmolive, Belgium
- 6 months internship
2005 - 2005Project within the R&D team of Colgate-Palmolive:
- Characterization and optimization of model perfume molecules deposit on textile fibres from a rinse cycle fabric softener / Improvement of olfactory impact of fabrics
- High experience on SPME, HPLC and dynamic rheology
- Study of perfume release through polymeric microcapsules
Clariant Ltd, UK
- 3 months internship
2004 - 2004Project within the production plant - Clariant Ltd, Horsforth:
- Installation and commissioning of an inline viscometer into a 5000 Lts reactor in order to control and optimize the “Cartafix range of products” manufacturing process
TOXLAB, Paris
- 3 months internship
2003 - 2003Project within a legal laboratory of expertise TOXLAB:
- Identification, titration and origin comparison of psycho active substances
- Techniques: HPLC/DA, GC/MS, GC/FID
Nottingham Trent University, UK
- 3 months internship
2002 - 2002Project within the research laboratories at the Nottingham Trent University:
- Synthesis of imprinted macro polymers for carbon hydrates using the concept of “Covalent Molecular Imprinting” method
