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Nadejda VINTONENKO

VILLEMOMBLE

En résumé

Scientist in Cancer Biology field with the experience of over 6 years in academic institutions, I also followed an additional training in Clinical Research area, and I have a strong desire to integrate Pharmaceutical industry.
I have developed a wealth of skills in conception, design and implementation of preclinical studies focused on novel therapies, using in vivo models in particular (orthotopic and sub-cutaneous primary tumor mouse models for breast cancer and glioblastoma, breast cancer metastasis model, CAM angiogenesis model). As a result of training as Clinical Research Associate I acquired good knowledge of GCP-ICH guidelines and current regulatory aspects, and good skills in routine CRA activities (essential documents review and TMF set up, protocol and ICF reviews and amendments, clinical sites initiations, CRF and eCRF monitoring, SAE reporting, IRB/IEC submission, query processing...)
My credentials are good communication, initiative and problem solving aptitudes, strong skills in experimental design. Excellent team player, I have also learned to work in autonomy. I am dedicated to do the best job possible from start to finish.
Ready to work and travel internationally, I wish to apply my scientific background along with fluency in English, French and Russian to establish and develop solid collaborations.

Mes compétences :
Biochemistry
Biology
Cell Biology
Clinical Research
English
French
in vivo
monitoring
Oncology
Pharmacology
Research

Entreprises

  • For Drug Consulting - Trainee

    2011 - maintenant Aquired good knowledge of GCP-ICH guidelines;
    Simulated using real anonymised documents: investigator evaluation and recruitment; Essential Document collection, review and maintenance; TMF set up, Clinical Site Initiation preparation and visits; monitoring and study tracking

  • ICM and Neurology Service led by Pr. Delattre, Hôpital de la Pitié-Salpêtrière - Scientist

    2010 - maintenant Studied molecular mechanisms determining response and relapse to anti-VEGF therapy in malignant gliomas.

    Search for prognostic molecular markers in gliomas using human tumor and plasma samples from brain tumor/plasma bank; coordination of plasma collection and storage from patients with malignant glioma, plasma bank maintenance; animal experimentation (orthotopic and subcutaneous glioblastoma mouse models); angiogenesis assay in chick embryo CAM; coordination of collaboration with Caen CYCERON Center (in vivo imaging, ex vivo organotypic glioma invasion model using mouse brain slices); stem and primary cell culture, cell-based assays; qRT-PCR assays and sequencing, ...

  • Pr. A. Carpentier Laboratory (HEGP, Paris) and Neurology Service at Avicenne Hospital (Bobigny) - Scientist

    2009 - 2009 Search for gliobrastoma prognostic markers predicting responce to Immunotherapy.

    Animal experimentation (paraneoplastic syndrome model); search for prognostic molecular markers in gliomas using human samples from brain tumor bank, set up and performance of qRT-PCR assays; recombinant protein production for its administration in vivo

  • INSERM U553 – Hôpital St. Louis, Paris and CNRS UMR7033 – Faculté de Médecine, Université Paris 13 - Scientist

    2007 - 2009 Search for novel anti-metastasis therapies and targets in breast cancer.

    Pharmacogenomic comparative study of statins versus bisphosphonates as novel anti-metastasis treatments, animal experimentation (breast cancer orthotopic, subcutaneous, and metastasis mouse models), transcriptomic approach set up and application (Affymetrix GeneChip), cell-based assays, Flow cytomemtry (FACS), biochemical assays (ELISA, WB, IP, zymography,etc),...

  • Institut de Biologie de Lille - Post-doctoral Fellow

    2004 - 2006 Studied mechanistic aspects of oncoprotein Ets-1 regulation.

    Search for transcriptional partners via purification of ptotein complexes using chromatography (FPLC, HPLC); molecular biology techniques (cloning, mutagenesis studies, gel shift assay,..), promoter transactivation assays, biochemical tests (IP, WB, ELISA...)

Formations

  • For Drug Consulting

    Malakoff 2011 - 2011 Clinical Research Associate courses

  • Bowling Green State University (Bowling Green)

    Bowling Green 1999 - 2004 PhD: Protein-Protein Interactions during photosynthesis in cyanobacteria

    Teaching Assistantship : Chemistry and Bichemistry Labs and Recitations, 1999-2004

  • Mendeleyev University Of Chemical Technology Of Russia MUCTR (Moscow)

    Moscow 1993 - 1999 Chemical Engineering, Polymers for medical use

    Teaching: school English courses, elementary/intermediate levels (1998-1999); Assistant at Foreign Languages Learning Center (1997-1999)

Réseau

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