Caroline DUBROCA

En résumé

Entreprises

• Cardiomedex - Project manager / Head of preclinical platform

  Labège 2011 - maintenant Cardiomedex is a CRO specialized in cardiovascular diseases and complications.
  
  In charge of:
  - Project management (budget, planification, study plan, study follow-up, data analysis, final reports)
  - Operational management
  - Customer relationship management
  - Consultancy work
  - Service offer establishment and brochure conception
  - Business database and web site development in collaboration with Business Development and Marketing Manager
  
  Specific expertise leveraging the preclinical platform of Cardiomedex:
  - Myocardial infarction (LAD coronary artery ligation)
  - Pressure overload-induced cardiac hypertrophy (thoracic aortic banding)
  - Heart failure
  - Hypertension
  - Combined diseases models with Hyperlipidemia, Obesity, Diabetes
  - Cardiac function assessment (pressure catheter, echocardiography, telemetry monitoring...)
  - Vascular reactivity (flow-mediated dilation, pressure-induced constriction, pharmacology...)

• Inserm - Researcher in Heart Failure Division, Institute of Cardiovascular and Metabolic Diseases, Toulouse

  PARIS 13 2011 - 2011 Theme: Heart failure and cardiac hypertophy
  
  Duties: Project research monitoring, Achievement of scientific experiments
  
  Technical skills: Coronary artery ligature induced myocardial infarction, thoracic aortic constriction, left ventricular pressure/volume loops analysis, echocardiography...

• Inserm - Researcher in Heart Failure Division, Inserm U970 - Paris Cardiovascular Research Center

  PARIS 13 2009 - 2010 Theme: Heart failure and cardiac hypertrophy
  
  Duties: Project research monitoring, Achievement of scientific experiments
  
  Technical skills: Micro-surgery, telemetry device implantation and monitoring, adult cardiomyocytes isolation for calcium transients and contractility assessment...

• SERVIER - Non Clinical Study Manager

  Suresnes 2008 - 2009 In charge of:
  - Project monitoring
  - Competitive intelligence
  - Evaluation of offers for sale or co-development of molecules
  
  Skills acquired: Preclinical development, Project managment

• SERVIER - Post-doctoral Reseacher

  Suresnes 2007 - 2008 In charge of project research influence of aging on flow-induced calcium response and NO pathway in endothelial cells
  
  Skills acquired: Endothelial cells isolation and culture, calcium signaling assessment in response to shear stress, Fluorescence imaging for intracellular calcium measurements
  
  

• Unit of Pharmacology and Therapeutics, UCL (Bruxelles) - Post-doctoral Researcher

  2005 - 2006 Director: Dr Jena-Luc Balligand
  
  In charge of research project: Role of endothelial nitric oxide synthase (eNOS) in cardiac stem cells differenciation
  
  Skills acquired: Neonatal cardiomyocytes and cardiac stem cells isolation, cell culture, Immunochemistry...

• Inserm - PhD student

  PARIS 13 2001 - 2005 Supervisor: Dr Daniel Henrion, Director: Dr Alain Tedgui
  
  Theme: Myogenic tone mechanotransduction: pathways and pathophysiological implications
  
  Skills acquired: Vascular reactivity and specially flow-mediated dilation and pressure-induced constriction assessment in resistance arteries mounted in a pressure myograph, Micro-dissection, Molecular biology...

• Pierre Fabre - Trainee

  Castres 2001 - 2001 Characterization of calcitonin gene related peptide-induced relaxation in cerebral arteries

Formations

• Université Denis Diderot (Paris VII) / University Paris VII

  Paris 2001 - 2005 PhD of Biology and Pharmacology of Haemostasis and Vessels

• University Of Poitiers

  Poitiers 2000 - 2001 Master of cell engineering: Methods of in vitro assessment of pharmaceuticals, cosmetics and other xenobiotics

Réseau

• Bénédicte PRUNET

  Op2 Drugs (Pessac)

• Beneton MAUD

• Fabienne AILLET

• Guillaume FERNANDEZ

• Justine BRICOUT

• Laurence GUICHERD-ROGIER

• Mathieu MAIRE

• Nicolas MANDARD

• Quentin THIEBLEMONT

• Yara BARREIRA