CHU Pasteur
- Ingénieur en Bio-Informatique
2007 - maintenant
Missions :
- Responsable informatique du service
- Gestion des annotations cliniques, anatomopathologiques et biologiques des prélèvements du laboratoire. Contrôles de l’intégrité des données.
- Conceptualisation, développement et tests de nouveaux outils informatiques
- Chef de projets
- Etudes statistiques descriptives, analyses de survie, paramétriques et non paramétriques
- Analyses Bio-Informatiques : Puces à ADN, ARN et micro ARN. Elaboration de clustering hiérarchique
- Participation à des études multicentriques : AIR, TVN, Mésobank, Melbase, Cryostem
- Interfaçage avec l’Institut National du CAncer
- Gestion des consentements (recueil et aspect législatif)
Publications :
2020 :
- Real-world assessment of the BRAF status in non-squamous cell lung carcinoma using VE1 immunohistochemistry: A single laboratory experience (LPCE, Nice, France)
Véronique Hofman, Jonathan Benzaquen, Simon Heeke, Sandra Lassalle, Michel Poudenx, Elodie Long, Elisabeth Lantéri, Olivier Bordone, Virginie Lespinet, Virginie Tanga, Christelle Bonnetaud, Yvonne Bille, Marius Ilié, Charles Marquette, Fabrice Barlesi, Jacques Boutros, Paul Hofman
Lung Cancer, 2020 Jul;145:58-62. doi: 10.1016/j.lungcan.2020.04.024. Epub 2020 May 5.
- Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France)
Sandra Lassalle, Véronique Hofman, Simon Heeke, Jonathan Benzaquen, Elodie Long, Michel Poudenx, Elisabeth Lantéri, Jacques Boutros, Virginie Tanga, Katia Zahaf, Salomé Lalvée, Virginie Lespinet, Olivier Bordone, Jean-Marc Félix, Christelle Bonnetaud, Charles Marquette, Marius Ilie, Paul Hofman
Cancers (Basel) 2020 Apr 13;12(4):955. doi: 10.3390/cancers12040955.
- Prospective evaluation of NGS-based liquid biopsy in untreated late stage non-squamous lung carcinoma in a single institution
Simon Heeke, Véronique Hofman, Marius Ilié, Maryline Allegra, Virginie Lespinet, Olivier Bordone, Jonathan Benzaquen, Jacques Boutros, Michel Poudenx, Salomé Lalvée, Virginie Tanga, Carole Salacroup, Christelle Bonnetaud, Charles-Hugo Marquette, Paul Hofman
2019 :
- Redefining Malignant Pleural Mesothelioma Types as a Continuum Uncovers Immune-Vascular Interactions
Nicolas Alcala, Lise Mangiante, Nolwenn Le-Stang, Corinne E Gustafson, Sandrine Boyault, Francesca Damiola, Karine Alcala, Marie Brevet, Françoise Thivolet-Bejui, Cécile Blanc-Fournier, Jean-Philippe Le Rochais, Gaëtane Planchard, Nathalie Rousseau, Diane Damotte, Jean Claude Pairon, Marie Christine Copin, Arnaud Scherpereel, Eric Wasielewski, Laurence Wicquart, Stéphanie Lacomme, Jean-Michel Vignaud, Gaspard Ancelin, Cécile Girard, Christine Sagan, Christelle Bonnetaud, Véronique Hofman, Paul Hofman, Jérôme Mouroux, Vincent Thomas de Montpreville, Estelle Clermont-Taranchon, Julien Mazieres, Isabelle Rouquette, Hugues Begueret, Jean-Yves Blay, Sylvie Lantuejoul, Raphael Bueno, Christophe Caux, Nicolas Girard, James D McKay, Matthieu Foll, Françoise Galateau-Salle, Lynnette Fernandez-Cuesta
EBioMedicine, 2019 Oct;48:191-202. doi: 10.1016/j.ebiom.2019.09.003. Epub 2019 Oct 21.
- Critical Assessment in Routine Clinical Practice of Liquid Biopsy for EGFR Status Testing in Non-Small-Cell Lung Cancer: A Single-Laboratory Experience (LPCE, Nice, France).
Simon Heeke, Jonathan Benzaquen, Véronique Hofman, Marius Ilié, Maryline Allegra, Elodie Long-Mira, Sandra Lassalle, Virginie Tanga, Carole Salacroup, Christelle Bonnetaud, Julien Fayada, Loïc Gazoppi, Lydia Ribeyre, Olivier Castelnau, Georges Garnier, Florian Cattet, Isabelle Nanni, Florence de Fraipont, Charlotte Cohen, Jean-Philippe Berthet, Sylvie Leroy, Michel Poudenx, Charles Hugo Marquette, Marc G Denis, Fabrice Barlesi, Paul Hofman
Clin Lung Cancer, 2020 Jan;21(1):56-65.e8. doi: 10.1016/j.cllc.2019.07.010. Epub 2019 Aug 3.
2018 :
- Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients.
Long-Mira E, Ilie M, Chamorey E, Leduff-Blanc F, Montaudié H, Tanga V, Allégra M, Lespinet-Fabre V, Bordone O, Bonnetaud C, Schiappa R, Butori C, Bence C, Lacour JP, Hofman V, Hofman P.
Oncotarget. 2018 Nov 16;9(90):36238-36249. doi: 10.18632/oncotarget.26343. eCollection 2018 Nov 16
- Establishing a Dedicated Lung Cancer Biobank at the University Center Hospital of
Nice (France). Why and How?
Washetine K, Heeke S, Bonnetaud C, Kara-Borni M, Ilié M, Lassalle S, Butori C, Long-Mira E, Marquette CH, Cohen C, Mouroux J, Selva E, Tanga V, Bence C, Félix JM, Gazoppi L, Skhiri T, Gormally E, Boucher P, Clément B, Dagher G, Hofman V, Hofman P.
Cancers (Basel). 2018 Jun 29;10(7). pii: E220. doi: 10.3390/cancers10070220
- Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA,
Washetine K, Kara-Borni M, Heeke S, Bonnetaud C, Félix JM, Ribeyre L, Bence C, Ilié M, Bordone O, Pedro M, Maitre P, Tanga V, Gormally E, Mossuz P, Lorimier P, Marquette CH, Mouroux J, Cohen C, Lassalle S, Long-Mira E, Clément B, Dagher G, Hofman V, Hofman P.
Cancers (Basel). 2018 Jun 11;10(6). pii: E195. doi: 10.3390/cancers10060195.
2016 :
- PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1+ and CD8+ tumor-infiltrating T cells and outcome,
Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P.
Mod Pathol. 2016 Dec;29(12):1552-1564. doi: 10.1038/modpathol.2016.149. Epub 2016 Aug 26.
- Study of LAT1 Expression in Brain Metastases: Towards a Better Understanding of the Results of Positron Emission Tomography Using Amino Acid Tracers.
Papin-Michault C, Bonnetaud C, Dufour M, Almairac F, Coutts M, Patouraux S, Virolle T, Darcourt J, Burel-Vandenbos F.
PLoS One. 2016 Jun 8;11(6):e0157139. doi: 10.1371/journal.pone.0157139. eCollection 2016.
- MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib,
Lassalle S, Zangari J, Popa A, Ilie M, Hofman V, Long E, Patey M, Tissier F, Belléannée G, Trouette H, Catargi B, Peyrottes I, Sadoul JL, Bordone O, Bonnetaud C, Butori C, Bozec A, Guevara N, Santini J, Hénaoui IS, Lemaire G, Blanck O, Vielh P, Barbry P, Mari B, Brest P, Hofman P.
Oncotarget. 2016 May 24;7(21):30461-78. doi: 10.18632/oncotarget.8458.
- High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the assessment of disease aggressiveness, Long E, Ilie M, Bence C, Butori C, Selva E, Lalvée S, Bonnetaud C, Poissonnet G, Lacour JP, Bahadoran P, Brest P, Gilson E, Ballotti R, Hofman V, Hofman P.
Cancer Med. 2016 Jun;5(6):1022-30. doi: 10.1002/cam4.661. Epub 2016 Mar 6.
2014 :
- Clinical value of circulating endothelial cells and of soluble CD146 levels in patients undergoing surgery for non-small cell lung cancer.
Ilie M, Long E, Hofman V, Selva E, Bonnetaud C, Boyer J, Vénissac N, Sanfiorenzo C, Ferrua B, Marquette CH, Mouroux J, Hofman P.
Br J Cancer. 2014 Mar 4;110(5):1236-43. doi: 10.1038/bjc.2014.11. Epub 2014 Jan 28.
- Diagnostic value of immunohistochemistry for the detection of the BRAF(V600E) mutation in papillary thyroid carcinoma: comparative analysis with three DNA-based assays
Marius I Ilie, Sandra Lassalle, Elodie Long-Mira, Christelle Bonnetaud, Olivier Bordone, Virginie Lespinet, Aude Lamy, Jean-Christophe Sabourin, Juliette Haudebourg, Catherine Butori, Nicolas Guevara, Isabelle Peyrottes, Jean-Louis Sadoul, Alexandre Bozec, José Santini, David Capper, Andreas von Deimling, Jean-François Emile, Véronique Hofman, Paul Hofman
Comparative Study Thyroid . 2014 May;24(5):858-66. doi: 10.1089/thy.2013.0302.
2013 :
- [The accreditation of a surgical pathology and somatic genetic laboratory (LPCE, CHU of Nice) according to the ISO 15189 norm: Sharing of experience].
Washetine K, Long E, Hofman V, Lassalle S, Ilie M, Lespinet V, Bonnetaud C, Bordone O, Gavric-Tanga V, Selva E, Reverso-Meinietti J, Sadoulet D, Lacour L, Bille Y, Lavagna R, Grier P, Zahaf K, Mari M, Hofman P.
Ann Pathol. 2013 Dec;33(6):386-97. doi: 10.1016/j.annpat.2013.10.002. Epub 2013 Nov 14. French.
- [Setting up a department of molecular pathology in oncology in a pathology laboratory (LPCE, CHU de Nice)].
Long E, Hofman V, Ilie M, Lespinet V, Bonnetaud C, Bordone O, Gavric-Tanga V, Washetine K, Gaziello MC, Mauro V, Lassalle S, Selva E, Zahaf K, Santini J, Castillo L, Lacour JP, Vénissac N, Mouroux J, Otto J, Poudenx M, Marquette CH, Sabourin JC, Hofman P.
Ann Pathol. 2013 Feb;33(1):24-37. doi: 10.1016/j.annpat.2012.12.003. Epub 2013 Jan 30. French
- [Accreditation of the activity of molecular pathology according to ISO 15189: key steps to follow and the main potential pitfalls].
Long E, Hofman V, Ilie M, Washetine K, Lespinet V, Bonnetaud C, Bordone O, Gavric-Tanga V, Gaziello MC, Lassalle S, Selva E, Zahaf K, Lamy A, Sabourin JC, Hofman P.
Ann Pathol. 2013 Feb;33(1):12-23. doi: 10.1016/j.annpat.2012.11.004. Epub 2013 Jan 30. French
2012 :
- [Setting up indicators in biobanking: why and how?].
Hofman V, Gaziello MC, Bonnetaud C, Ilie M, Mauro V, Long E, Selva E, Gavric-Tanga V, Lassalle S, Butori C, Papin-Michaud C, Lerda N, Bordone O, Coelle C, Sabourin JC, Chabannon C, Hofman P.
Ann Pathol. 2012 Apr;32(2):91-101. doi: 10.1016/j.annpat.2012.02.002. Epub 2012 Mar 28. French.
- Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer.
Ilie M, Hofman V, Ortholan C, Bonnetaud C, Coëlle C, Mouroux J, Hofman P.
Cancer. 2012 Mar 15;118(6):1726-37. doi: 10.1002/cncr.26456. Epub 2011 Aug 25
2011 :
- MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells.
Brest P, Lassalle S, Hofman V, Bordone O, Gavric Tanga V, Bonnetaud C, Moreilhon C, Rios G, Santini J, Barbry P, Svanborg C, Mograbi B, Mari B, Hofman P.
Endocr Relat Cancer. 2011 Nov 14;18(6):711-9. doi: 10.1530/ERC-10-0257. Print 2011 Dec.
- Can the microRNA signature distinguish between thyroid tumors of uncertain malignant potential and other well-differentiated tumors of the thyroid gland?
Lassalle S, Hofman V, Ilie M, Bonnetaud C, Puisségur MP, Brest P, Loubatier C, Guevara N, Bordone O, Cardinaud B, Lebrigand K, Rios G, Santini J, Franc B, Mari B, Al Ghuzlan A, Vielh P, Barbry P, Hofman P.
Endocr Relat Cancer. 2011 Sep 13;18(5):579-94. doi: 10.1530/ERC-10-0283. Print 2011 Oct.
- Setting up a Prospective Thyroid Biobank for Translational Research: Practical Approach of a Single Institution (2004-2009, Pasteur Hospital, Nice, France).
Lassalle S, Hofman V, Ilie M, Butori C, Bonnetaud C, Gaziello MC, Selva E, Gavric-Tanga V, Guevara N, Castillo L, Santini J, Chabannon C, Hofman P.
Biopreserv Biobank. 2011 Mar;9(1):9-19. doi: 10.1089/bio.2010.0024. Epub 2011 Mar 22
- Morphological analysis of circulating tumour cells in patients undergoing surgery for non-small cell lung carcinoma using the isolation by size of epithelial tumour cell (ISET) method.
Hofman V, Long E, Ilie M, Bonnetaud C, Vignaud JM, Fléjou JF, Lantuejoul S, Piaton E, Mourad N, Butori C, Selva E, Marquette CH, Poudenx M, Sibon S, Kelhef S, Vénissac N, Jais JP, Mouroux J, Molina TJ, Vielh P, Hofman P.
Cytopathology. 2012 Feb;23(1):30-8. doi: 10.1111/j.1365-2303.2010.00835.x. Epub 2011 Jan 6.
- Cytopathologic detection of circulating tumor cells using the isolation by size of epithelial tumor cell method: promises and pitfalls.
Hofman VJ, Ilie MI, Bonnetaud C, Selva E, Long E, Molina T, Vignaud JM, Fléjou JF, Lantuejoul S, Piaton E, Butori C, Mourad N, Poudenx M, Bahadoran P, Sibon S, Guevara N, Santini J, Vénissac N, Mouroux J, Vielh P, Hofman PM.
Am J Clin Pathol. 2011 Jan;135(1):146-56. doi: 10.1309/AJCP9X8OZBEIQVVI.
- Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay™ and the isolation by size of epithelial tumor cell method.
Hofman V, Ilie MI, Long E, Selva E, Bonnetaud C, Molina T, Vénissac N, Mouroux J, Vielh P, Hofman P.
Int J Cancer. 2011 Oct 1;129(7):1651-60. doi: 10.1002/ijc.25819. Epub 2011 Mar 11.
- Preoperative circulating tumor cell detection using the isolation by size of epithelial tumor cell method for patients with lung cancer is a new prognostic biomarker.
Hofman V, Bonnetaud C, Ilie MI, Vielh P, Vignaud JM, Fléjou JF, Lantuejoul S, Piaton E, Mourad N, Butori C, Selva E, Poudenx M, Sibon S, Kelhef S, Vénissac N, Jais JP, Mouroux J, Molina TJ, Hofman P.
Clin Cancer Res. 2011 Feb 15;17(4):827-35. doi: 10.1158/1078-0432.CCR-10-0445. Epub 2010 Nov 23.
2010 :
- [The Nice CHU biobank experience to collect patients' informed consent for research context (2004-2009)].
Hofman V, Bonnetaud C, Gaziello MC, Ilie M, Lassalle S, Butori C, Lerda N, Selva E, Gavric-Tanga V, Castillo L, Guevara N, Santini J, Pop D, Vénissac N, Mouroux J, Chabannon C, Hofman P.
Ann Pathol. 2010 Oct;30(5):337-43. doi: 10.1016/j.annpat.2010.09.002. Epub 2010 Oct 16. French.
- Usefulness of tissue microarrays for assessment of protein expression, gene copy number and mutational status of EGFR in lung adenocarcinoma.
Ilie MI, Hofman V, Bonnetaud C, Havet K, Lespinet-Fabre V, Coëlle C, Gavric-Tanga V, Vénissac N, Mouroux J, Hofman P.
Virchows Arch. 2010 Oct;457(4):483-95. doi: 10.1007/s00428-010-0963-z. Epub 2010 Aug 28.
- Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis.
Ilie MI, Hofman V, Ortholan C, Ammadi RE, Bonnetaud C, Havet K, Venissac N, Mouroux J, Mazure NM, Pouysségur J, Hofman P.
Int J Cancer. 2011 Apr 1;128(7):1614-23. doi: 10.1002/ijc.25491. Epub 2010 Jun 2.
- High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer.
Ilie M, Mazure NM, Hofman V, Ammadi RE, Ortholan C, Bonnetaud C, Havet K, Venissac N, Mograbi B, Mouroux J, Pouysségur J, Hofman P.
Br J Cancer. 2010 May 25;102(11):1627-35. doi: 10.1038/sj.bjc.6605690. Epub 2010 May 11.
- [Publication of biological samples collections catalogues by tumor banks].
Chabannon C, Honstettre A, Daufresne LM, Martin PM, Bonnetaud C, Birtwisle-Peyrottes I, Romain S, Achache K, Mery O, Bordonne O, Ducord C, Jacotot L, Vaglio P, d'Arnoux C, Figarella-Branger D, Hofman P, Borg JP, Atger V.
Bull Cancer. 2010 Feb;97(2):181-9. doi: 10.1684/bdc.2009.0963. French.
2009 :
- Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility.
Hofman V, Lassalle S, Bonnetaud C, Butori C, Loubatier C, Ilie M, Bordone O, Brest P, Guevara N, Santini J, Franc B, Hofman P.
Virchows Arch. 2009 Jul;455(1):21-33. doi: 10.1007/s00428-009-0798-7. Epub 2009 Jun 20
