Marianne DUHAMEL


En résumé

Mes compétences :
Project management
Team management
Cell biology
Molecular Biology
Biologie moléculaire
Biologie cellulaire
Gestion de projet


  • Sanofi - CGMP Cell Banks manufacturing

    Paris 2014 - maintenant
  • Cellectis bioresearch (Ectycell) - Project Leader

    2010 - 2014 Evry (91) - Paris (75)

    In charge of iPS cells genome engineering projects, as part of Cellectis bioresearch iPS Hub offer:

    -> Implementation of iPS engineering platform: Lab organisation, Engineering processes development (KI, KO, nucleotide substitution), standard operating procedures drafting, LIMS interface development with Bioinformatics group, coordination with Regulatory Affairs, QA and Customer Support Departments.

    -> Management of iPS engineering contracts for iPS Hub customers:
    - Design of engineering strategies and tools,
    - Tasks planning, resources allocation
    - Daily management of lab work (up to 5 production assistants)
    - Progress and final reporting to senior managers, customer support and clients

    -> Interaction with Swedish genome engineering team, focused on hESC programs.

  • Sanofi-Aventis - Research scientist

    Paris 2008 - 2010 March 2008 to March 2010, Research Scientist, SANOFI-AVENTIS, Oncology department, Montpellier (34).

    Early & advanced oncology research programs:
    - Biological validation of potential oncology targets: cell culture, siRNA, cell proliferation (14C, 3H), cell viability, image fluorescence (HCS, BD Pathway)
    - Determination of cellular read-out and death mechanisms, research of drug activity and efficacy biomarkers: WB, IP, Meso Scale, ELISA, tumors/surrogate tissues.
  • INSERM - PhD student

    PARIS 13 2004 - 2007 Pitié-Salpêtrière Hospital, Cellular and Tissular Immunology laboratory

    Molecular mechanisms analysis of Aiolos transcription factor regulation in immune cells. Application to Chronic Lymphoid Leukaemia:
    - Design and development of two new research topics, Epigenetic and lymphoproliferative disorders, in a programmed cell death specialized team
    - Collaborative work: Pitié-Salpêtrière Biological Haematology Laboratory, Pasteur Institute
    - 7 publications
    - Training of the team students to molecular and cellular biology techniques
  • L'Oréal - Research engineer

    PARIS 2002 - 2003 Aulnay sous bois (93, France), Cutaneous safety laboratory, 14 months alternate internship

    Improvement of human reconstructed epidermis models. Application to cutaneous toxicity assessment.
    - Culture conditions optimization and assessment of irritation detection sensitivity
    - Development of a Good Laboratory Practice quality management system