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Karen HINSINGER

Gif-sur-Yvette

En résumé

Mes compétences :
Chimie fine
R&D
Chimie analytique
Chimie
Gestion de projet
Ingénierie
Communication

Entreprises

  • CEA Saclay - Research associate

    Gif-sur-Yvette 2013 - maintenant SYNTHESIS OF TOXIN INHIBITORS (RICIN AND SHIGA TOXIN)

    Keywords: medicinal chemistry, heterocyclic chemistry, photoaffinity labelling, Isotopic labelling, SAR studies.
  • Cardiff School of Pharmacy and Pharmaceutical Sciences - Research associate

    2011 - 2013 "DESIGN AND SYNTHESIS OF ANTIVIRAL NUCLEOTIDES"

    Keywords: medicinal chemistry, nucleosides, nucleotides, prodrugs (ProTides), heterocycle chemistry.
  • Laboratoire des Glucides-UMR6219 - PhD in organic chemistry

    2007 - 2010 SYNTHESIS OF GLYCO-YNITOLS AND ALPHA-HYDROXYALLENES :
    STUDY OF THEIR INTRAMOLECULAR CYCLISATIONS TO POLYFONCTIONNALISED STRUCTURES.

    The aim of this project was the synthesis of polyhydroxylated bicyclic heterocycles by intramolecular cyclisation of chiral acyclic alkynes, named glyco-ynitols.
    After having prepared these intermediates via regioselective transformation of monosaccharides, we firstly studied 1,3-dipolar cycloadditions in order to obtain pyrrolidine, pyrazoline and pyrazole compounds. Then, a hetero-Pauson-Khand reaction yielded butenolides.
    We also looked into the synthesis of exocyclic alpha-hydroxyallenes. Consequently we tested different cyclisation conditions of glyco-ynitols with Bronsted and Lewis acids. Afterwards, gold(III)-catalyzed cycloisomerisation of the obtained allenes was realized to yield 2,5-dihydrofuran bicycles.
  • Hoffmann-La Roche - Research technician

    2005 - 2006 I synthesized a library of coumpounds (organic synthesis, purification and analyse of compounds) and to interpret biological and physico-chemical data.

Formations

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