Laboratoire des Glucides-UMR6219
- PhD in organic chemistry
2007 - 2010SYNTHESIS OF GLYCO-YNITOLS AND ALPHA-HYDROXYALLENES :
STUDY OF THEIR INTRAMOLECULAR CYCLISATIONS TO POLYFONCTIONNALISED STRUCTURES.
The aim of this project was the synthesis of polyhydroxylated bicyclic heterocycles by intramolecular cyclisation of chiral acyclic alkynes, named glyco-ynitols.
After having prepared these intermediates via regioselective transformation of monosaccharides, we firstly studied 1,3-dipolar cycloadditions in order to obtain pyrrolidine, pyrazoline and pyrazole compounds. Then, a hetero-Pauson-Khand reaction yielded butenolides.
We also looked into the synthesis of exocyclic alpha-hydroxyallenes. Consequently we tested different cyclisation conditions of glyco-ynitols with Bronsted and Lewis acids. Afterwards, gold(III)-catalyzed cycloisomerisation of the obtained allenes was realized to yield 2,5-dihydrofuran bicycles.
Hoffmann-La Roche
- Research technician
2005 - 2006I synthesized a library of coumpounds (organic synthesis, purification and analyse of compounds) and to interpret biological and physico-chemical data.
Between the second and the third year, I realised a one year internship as research technician in a medicinal chemistry group at Hoffmann-La Roche in Basel (Switzerland).
