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Maël LE BERRE

PARIS 5

En résumé

Researcher in Microfluidics and cell mechanics in Curie Institute (Team of Matthieu Piel, UMR144), co-founder of the Start-up Elvesys.

Publication List and Citation Metrics:
http://www.researcherid.com/rid/E-3538-2010

Mes compétences :
Cell Biology
Instrumentation
Engineering
Microfluidique

Entreprises

  • Institut Curie - PostDoc

    PARIS 5 2009 - maintenant Migration, Prolifération et Division cellulaire en milieu confiné.

    http://umr144.curie.fr/en/research-groups/systems-cell-biology-cell-polarity-and-cell-division-matthieu-piel/systems-cell-biol

  • Elvesys - Scientific Advisor

    2009 - maintenant http://www.elvesys.com/

  • Ecole Normale Supérieure - PhD student

    2005 - 2009 Advisor: Yong CHEN, Damien BAIGL

    Matter deposition and pattern formation on a solid surface: Microfluidic methods, Control by capillary forces, and Generation of giant vesicles.

    The objective of this work was to develop new methods of deposition and patterning in order to better control the organisation of molecules of biological interest on a solid substrate.
    In the first part of the manuscript, we present an original method, the micro-aspiration, which allowed us to reversibly assemble microfluidic channels and to guide liquids through it. We have studied the properties of these systems with simple physical models and fabricated patterns of polymers, nanoparticles, gels, etc.
    In the second part, we explored new deposition methods of multilayered phospholipid films on solid substrates and applied it to the fabrication of giant unilamellar vesicles of controlled size. First, the adaptation of conventional techniques (microcontact printing, molding, etc.) allowed us to obtain phospholipid patterns of micrometric size. The deposition has been realized afterward using a receding meniscus under evaporation (capillary assembling). Two deposition regimes have been identified depending on the relative importance of evaporation and viscous forces, allowing a control of the film thickness up to 200 nm with a bilayer resolution. The appearance of wetting instabilities or the guidance with microstructures allowed us to obtain patterns of various shapes. By using these substrates as electrodes, we obtained giant unilamellar vesicles of controlled size by electroformation. All these results open new perspectives for the fabrication of surfaces and micro-patterns of biological interest.

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